Spinal signalling of C-fiber mediated pleasant touch in humansVisa övriga samt affilieringar
2019 (Engelska)Ingår i: eLIFE, E-ISSN 2050-084X, Vol. 8, artikel-id e51642Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.
Ort, förlag, år, upplaga, sidor
ELIFE SCIENCES PUBLICATIONS LTD , 2019. Vol. 8, artikel-id e51642
Nationell ämneskategori
Biofysik
Identifikatorer
URN: urn:nbn:se:liu:diva-163474DOI: 10.7554/eLife.51642ISI: 000508133000001PubMedID: 31872799OAI: oai:DiVA.org:liu-163474DiVA, id: diva2:1393673
Anmärkning
Funding Agencies|Pain Relief Foundation
2020-02-172020-02-172020-04-30