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OpenSFDI: an open-source guide for constructing a spatial frequency domain imaging system
Boston Univ., United States.
Boston Univ., United States.
Univ. de Strasbourg, France.
The Univ. of Maine, United States.
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2020 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 25, no 1Article in journal (Refereed) Published
Abstract [en]

Significance: Spatial frequency domain imaging (SFDI) is a diffuse optical measurement technique that can quantify tissue optical absorption (μa) and reduced scattering (μ0 s) on a pixelby-pixel basis. Measurements of μa at different wavelengths enable the extraction of molar concentrations of tissue chromophores over a wide field, providing a noncontact and label-free means to assess tissue viability, oxygenation, microarchitecture, and molecular content. We present here openSFDI: an open-source guide for building a low-cost, small-footprint, threewavelength SFDI system capable of quantifying μa and μ0 s as well as oxyhemoglobin and deoxyhemoglobin concentrations in biological tissue. The companion website provides a complete parts list along with detailed instructions for assembling the openSFDI system. Aim: We describe the design of openSFDI and report on the accuracy and precision of optical property extractions for three different systems fabricated according to the instructions on the openSFDI website. Approach: Accuracy was assessed by measuring nine tissue-simulating optical phantoms with a physiologically relevant range of μa and μ0 s with the openSFDI systems and a commercial SFDI device. Precision was assessed by repeatedly measuring the same phantom over 1 h. Results: The openSFDI systems had an error of 0 6% in μa and −2 3% in μ0 s, compared to a commercial SFDI system. Bland–Altman analysis revealed the limits of agreement between the two systems to be 0.004 mm−1 for μa and −0.06 to 0.1 mm−1 for μ0 s. The openSFDI system had low drift with an average standard deviation of 0.0007 mm−1 and 0.05 mm−1 in μa and μ0 s, respectively. Conclusion: The openSFDI provides a customizable hardware platform for research groups seeking to utilize SFDI for quantitative diffuse optical imaging.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2020. Vol. 25, no 1
Keywords [en]
spatial frequency domain imaging; modulated imaging; diffuse optics; frequency domain; optical properties; open source
National Category
Atom and Molecular Physics and Optics Medical Laboratory and Measurements Technologies Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:liu:diva-163696DOI: 10.1117/1.JBO.25.1.016002PubMedID: 31925946Scopus ID: 2-s2.0-85079344131OAI: oai:DiVA.org:liu-163696DiVA, id: diva2:1394205
Funder
Wallenberg FoundationsAvailable from: 2020-02-18 Created: 2020-02-18 Last updated: 2020-03-12Bibliographically approved

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Saager, Rolf B.

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