Vitamin D deficiency at the time of delivery - Prevalence and risk of postpartum infections.
2019 (Engelska)Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 14, nr 12, artikel-id e0226673Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
BACKGROUND: Postpartum infections are a common cause of morbidity after childbirth. Vitamin D deficiency has been shown to increase the risk for several infections in a non-pregnant population. Vitamin D deficiency has been described as common in pregnant women.
OBJECTIVE: To investigate whether vitamin D deficiency in pregnant women in labor was associated with an increased risk of overall postpartum infectious morbidity within eight weeks of delivery. A secondary aim was to estimate the prevalence of vitamin D deficiency among pregnant women in Linköping, Sweden at the time of delivery.
MATERIAL AND METHODS: Serum vitamin D levels in labor were analyzed for 1397 women. Vitamin D deficiency was defined as serum levels <50 nmol/L. All ICD-10 codes given to the women eight weeks postpartum were reviewed and postpartum infections were defined as the presence of an ICD-10 code suggestive of infection. The prevalence of postpartum infections among women with sufficient vitamin D levels was compared with women with vitamin D deficiency. Adjusted Odds Ratios and 95% confidence intervals for postpartum infections were calculated using multivariate logistic regression analysis.
RESULTS: Fifty eight per cent of the women had serum vitamin D levels <50 nmol/L. The proportion of women with vitamin D deficiency varied, as expected, with season. No association between vitamin D deficiency and postpartum infections was found. For vitamin D 25-50 nmol/L the adjusted Odds Ratio was 0.85 (95% confidence interval 0.56-1.29) and for vitamin D <25 nmol/L the adjusted Odds Ratio was 1.15 (95% confidence interval 0.66-2.03). Women who smoked or who had a cesarean section had an increased risk of postpartum infections.
CONCLUSIONS: Vitamin D deficiency was more common than previously reported in Swedish pregnant women. No association between vitamin D deficiency and postpartum infections was found. Other well-known risk factors for postpartum infection were identified.
Ort, förlag, år, upplaga, sidor
2019. Vol. 14, nr 12, artikel-id e0226673
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-163756DOI: 10.1371/journal.pone.0226673ISI: 000534249400057PubMedID: 31856242OAI: oai:DiVA.org:liu-163756DiVA, id: diva2:1394608
Anmärkning
Funding agencies: Futurum - the academy for healthcare, Region Jonko ping County, Sweden [879861, 711011, 712481]; ALF grants, Region Ostergotland, Sweden [LIO-794921, LIO-792621]
2020-02-192020-02-192021-06-14