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Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
Haukeland Hosp, Norway.
Feinstein Inst Med Res, NY USA.
Univ Calif Los Angeles, CA 90024 USA.
Univ New Mexico, NM 87131 USA.
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2020 (Engelska)Ingår i: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 87, nr 5, s. 451-461Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohens d = 1.01, p amp;lt; .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p amp;lt; .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearmans rank correlation rho = -.44, p amp;lt; .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.

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Elsevier, 2020. Vol. 87, nr 5, s. 451-461
Nyckelord [en]
Antidepressant; Biomarker; Brain; Depression; ECT; Magnetic resonance imaging; Neuroimaging
Nationell ämneskategori
Neurologi
Identifikatorer
URN: urn:nbn:se:liu:diva-163872DOI: 10.1016/j.biopsych.2019.07.010ISI: 000511835600011PubMedID: 31561859Scopus ID: 2-s2.0-85072586816OAI: oai:DiVA.org:liu-163872DiVA, id: diva2:1395671
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Funding Agencies|Western Norway Regional Health Authority [911986, 912238]; University of Bergen; Fulbright Program; National Institute of Mental HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [MH092301, MH110008, U01 MH11826]; Interdisciplinary Center for Clinical Research of the Medical Faculty of Munster [Dan 3/012/17]; Lundbeck FoundationLundbeckfonden; Carlos III Health InstituteInstituto de Salud Carlos III [CPII16/00048]; Innovative Medical Research [RE111604, RE111722, RO1 MH111359, U24 DA041123]; German Research FoundationGerman Research Foundation (DFG) [FOR2107 DA1151/5-1, DA1151/5-2, SFB-TRR58]

Tillgänglig från: 2020-02-24 Skapad: 2020-02-24 Senast uppdaterad: 2021-04-30Bibliografiskt granskad

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