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Thymus Involution and Intravenous Drug Abuse
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Medicine and Health Sciences. Dept Forens Med, Artillerigatan 12, S-58758 Linkoping, Sweden.
2020 (English)In: American Journal of Forensic Medicine and Pathology, ISSN 0195-7910, E-ISSN 1533-404X, Vol. 41, no 1, p. 32-34Article in journal (Refereed) Published
Abstract [en]

Thymus glands from 283 autopsy cases were sampled and evaluated with histochemical and immunohistochemical methods. A subpopulation of 41 intravenous drug addicts were compared with age-matched control cases. It was found that an accelerated involution of the thymus occurred in the 20- to 25-year interval and thereafter with a steady pace of 5% per year. Also the size of Hassall bodies declined successively. In drug addicts, an increased dystrophic calcification of the Hassall bodies and a significant difference in thymus size (atrophy) compared with controls were seen. Moreover, a difference was seen in the relative numbers of CD4 and CD8 lymphocytes where CD4+ cells were reduced in drug addicts. It is hypothesized that signs of hepatitis C virus infection that was found in the majority of drug addicts and the reduced number of functionally intact Hassall corpuscles could explain the reduction of CD4+ lymphocytes and thymic hypotrophy in this population.

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2020. Vol. 41, no 1, p. 32-34
Keywords [en]
thymus; drug addiction; forensic medicine; pathology; immunohistochemistry
National Category
Forensic Science
Identifiers
URN: urn:nbn:se:liu:diva-164195DOI: 10.1097/PAF.0000000000000530ISI: 000514916700007PubMedID: 32000220OAI: oai:DiVA.org:liu-164195DiVA, id: diva2:1413961
Note

Funding Agencies|Swedish National Board of Forensic Medicine [4155453]

Available from: 2020-03-11 Created: 2020-03-11 Last updated: 2020-03-11

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CiteExportLink to record
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Citation style
  • apa
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