liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association between occurrence of urinary bladder cancer and treatment with statin medication
Umeå Univ, Sweden.
Lund Univ Hosp, Sweden.
Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland. Linköping University, Faculty of Medicine and Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Urology in Östergötland.
2019 (English)In: TURKISH JOURNAL OF UROLOGY, ISSN 2149-3235, Vol. 45, no 2, p. 97-102Article in journal (Refereed) Published
Abstract [en]

Objective: The incidence of urinary bladder cancer (UBC) has increased in Sweden despite decreased smoking, indicating that other factors might be associated. The increased use of statin medication for elevated blood lipids might be one such influencing factor. The aim of the present study was to assess whether statins are afflicted with an increased incidence of UBC. Material and methods: Data from the Swedish National Register of Urinary Bladder Cancer, National Population Register, and Swedish Prescribed Drug Register were extracted. There were 22,936 patients with new diagnosed UBC between 2005 and 2014. Statin prescription was defined as any medication prescribed with the Anatomical Therapeutic Classification code C10A. For each patient, 10 control individuals were matched by age, gender, and living area, comprising 229,326 individuals. The Cochran-Mantel-Haenszel test was used to evaluate the hazards ratios. Results: Statins were more frequently used in patients with UBC (33.8%) than in controls (29.8%, pamp;lt;0.0001). The use of statins was afflicted with a 23% increased odds ratio (OR) for UBC (OR 1.23 (1.19-1.27), pamp;lt;0.001). Subgroup analyses showed that an increased OR was found in non-muscle invasive UBC only. There was a tendency that OR was stronger for men and for younger patients. Limitations include its retrospective register-based design and potential risk of bias of confounding factors, such as smoking and body mass index. Conclusion: This nationwide register study suggests an association between the occurrence of UBC and patients using statins. The association was found in patients with non-muscle invasive disease only. Confounding factors, such as smoking, cannot be overruled.

Place, publisher, year, edition, pages
AVES , 2019. Vol. 45, no 2, p. 97-102
Keywords [en]
Diabetes; odds ratio; incidence; stage; smoking; statin medication; urinary bladder cancer
National Category
General Practice
Identifiers
URN: urn:nbn:se:liu:diva-164474DOI: 10.5152/tud.2019.94495ISI: 000459395400005PubMedID: 30875287OAI: oai:DiVA.org:liu-164474DiVA, id: diva2:1417416
Note

Funding Agencies|Umea University; Vasterbotten County Council; Lions Cancer Research Foundation in Umea

Available from: 2020-03-27 Created: 2020-03-27 Last updated: 2020-04-28

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Jahnson, Staffan

Search in DiVA

By author/editor
Jahnson, StaffanLjungberg, Börje
By organisation
Department of Urology in ÖstergötlandFaculty of Medicine and Health SciencesDivision of Surgery, Orthopedics and OncologyDepartment of Clinical and Experimental Medicine
General Practice

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 9 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf