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Hyaluronic Acid Accelerates Re-epithelialization and Alters Protein Expression in a Human Wound Model
Linköping University, Department of Clinical and Experimental Medicine, Division of Surgery, Orthopedics and Oncology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Hand and Plastic Surgery.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Local Health Care Services in Central Östergötland, Department of Emergency Medicine in Linköping.
Linköping University, Department of Medical and Health Sciences, Division of Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart and Medicine Center, Department of Dermatology and Venerology.
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2019 (English)In: PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN, ISSN 2169-7574, Vol. 7, no 5, article id e2221Article in journal (Refereed) Published
Abstract [en]

Background: Hyaluronic acid (HA), a large glycosaminoglycan involved in proliferation, migration, and tissue repair, is suggested to be an important factor for keratinocyte activation and re-epithelialization. The experimental hypothesis of this study was that HA accelerates re-epithelialization, and we aimed to investigate the effect of exogenous intradermal HA during deep dermal, incisional wound healing in vivo in humans, the primary endpoint being re-epithelialization. Methods: A total of 8 standardized deep dermal incisional wounds (depth 1.6mm, width 1.8mm) per subject were induced in 10 healthy volunteers. Two of the wound sites per subject were pretreated with injections of HA and 2 with saline solution. At 2 time points (24 hours and 14 days), 2 biopsies for each treatment group (one for histology and one for proteomics) were taken. Skin erythema was measured at 24-hour intervals for 14 days as a surrogate measurement of inflammation. Results: At 24 hours, 8 of 9 wounds pretreated with HA showed complete re-epithelization, whereas none of the wounds pretreated with saline had re-epithelized. Wounds pretreated with HA also showed a 10-fold regulation of 8 identified proteins involved in wound healing compared to wounds treated with saline solution. No difference in inflammation, as measured as erythema, could be seen between any of the groups. Conclusions: We conclude that HA accelerates re-epithelialization and stimulates an altered protein expression in vivo in human deep dermal incisional skin wounds, but has no effect on the inflammation process as measured by erythema.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2019. Vol. 7, no 5, article id e2221
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Surgery
Identifiers
URN: urn:nbn:se:liu:diva-164452DOI: 10.1097/GOX.0000000000002221ISI: 000480725100035PubMedID: 31333952OAI: oai:DiVA.org:liu-164452DiVA, id: diva2:1417442
Note

Funding Agencies|ALF Grants, Region Ostergotland, Sweden

Available from: 2020-03-28 Created: 2020-03-28 Last updated: 2020-04-15Bibliographically approved

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Nyman, ErikaHenricson, JoakimGhafouri, BijarAnderson, Chris D.Kratz, Gunnar

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Nyman, ErikaHenricson, JoakimGhafouri, BijarAnderson, Chris D.Kratz, Gunnar
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Division of Surgery, Orthopedics and OncologyFaculty of Medicine and Health SciencesDepartment of Hand and Plastic SurgeryDivision of Drug ResearchDepartment of Emergency Medicine in LinköpingDivision of Community MedicinePain and Rehabilitation CenterDivision of Cell BiologyDepartment of Dermatology and Venerology
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