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High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
Department of Ophthalmology, Ryhov County Hospital, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Science. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Ophthalmology in Linköping.ORCID iD: 0000-0003-1079-4361
Department of Ophthalmology, Ryhov County Hospital, Sweden.
Department of Ophthalmology, Ryhov County Hospital, Sweden.
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2019 (English)In: American journal of ophthalmology case reports, ISSN 2451-9936, Vol. 15, article id 100499Article in journal (Refereed) Published
Abstract [en]

Purpose

To describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial presentation.

Observations

An otherwise healthy 24-year old female presented with a severe unilateral keratitis. The diagnosis eluded clinicians for several months and when finally confirmed as AK, anti-amoebic therapy was instated and only appeared to be effective after addition of high fluence PACK-CXL.

Conclusion and importance

In this case of advanced AK, high fluence PACK-CXL treatment given adjuvant to pharmacologic anti-amoebic therapy resulted in lasting pain relief, re-epithelization and eradication of the Acanthamoeba parasite. Given adjuvant to anti-amoebic pharmacotherapy, high fluence PACK-CXL might be a useful method for treating typically refractory advanced AK.

Place, publisher, year, edition, pages
Elsevier, 2019. Vol. 15, article id 100499
Keywords [en]
Acanthamoeba keratitis; Phototherapy
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-164808DOI: 10.1016/j.ajoc.2019.100499PubMedID: 31312750Scopus ID: 2-s2.0-85068180159OAI: oai:DiVA.org:liu-164808DiVA, id: diva2:1420918
Available from: 2020-04-01 Created: 2020-04-01 Last updated: 2020-04-23Bibliographically approved

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Lagali, Neil SFagerholm, Per

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Division of Neuro and Inflammation ScienceFaculty of Medicine and Health SciencesDepartment of Ophthalmology in Linköping
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