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Neurobiology of alcohol seeking behavior
Linköping University, Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-5726-4814
Univ Gothenburg, Sweden.
Univ Gothenburg, Sweden.
Linköping University, Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Psykiatricentrum, Psykiatriska kliniken i Linköping.
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2021 (English)In: Journal of Neurochemistry, ISSN 0022-3042, E-ISSN 1471-4159, Vol. 157, no 5, p. 1585-1614Article, review/survey (Refereed) Published
Abstract [en]

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to stop or control alcohol use despite adverse consequences. A main challenge of addiction treatment is to prevent relapse, which occurs in more than >50% of newly abstinent patients with alcohol disorder within 3 months. In people suffering from alcohol addiction, stressful events, drug-associated cues and contexts, or re-exposure to a small amount of alcohol trigger a chain of behaviors that frequently culminates in relapse. In this review, we first present the preclinical models that were developed for the study of alcohol seeking behavior, namely the reinstatement model of alcohol relapse and compulsive alcohol seeking under a chained schedule of reinforcement. We then provide an overview of the neurobiological findings obtained using these animal models, focusing on the role of opioids systems, corticotropin-release hormone and neurokinins, followed by dopaminergic, glutamatergic, and GABAergic neurotransmissions in alcohol seeking behavior.

Place, publisher, year, edition, pages
Wiley , 2021. Vol. 157, no 5, p. 1585-1614
Keywords [en]
alcohol seeking; animal model; dopamine; GABA; glutamate; opioid receptors; relapse
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-175305DOI: 10.1111/jnc.15343ISI: 000637984400001PubMedID: 33704789OAI: oai:DiVA.org:liu-175305DiVA, id: diva2:1547567
Note

Funding Agencies|Swedish Research Council, VR projectSwedish Research Council [2018-02320]

Available from: 2021-04-27 Created: 2021-04-27 Last updated: 2022-03-22Bibliographically approved

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Domi, EsiHeilig, MarkusAugier, Eric
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Center for Social and Affective NeuroscienceFaculty of Medicine and Health SciencesPsykiatriska kliniken i Linköping
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