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Investigative genetic genealogy: Current methods, knowledge and practice
Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden; Oslo Univ Hosp, Norway.
Univ Santiago de Compostela, Spain.
UCL, England.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Molecular Medicine and Virology. Linköping University, Faculty of Medicine and Health Sciences. Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden.
2021 (English)In: Forensic Science International: Genetics, ISSN 1872-4973, E-ISSN 1878-0326, Vol. 52, article id 102474Article, review/survey (Refereed) Published
Abstract [en]

Investigative genetic genealogy (IGG) has emerged as a new, rapidly growing field of forensic science. We describe the process whereby dense SNP data, commonly comprising more than half a million markers, are employed to infer distant relationships. By distant we refer to degrees of relatedness exceeding that of first cousins. We review how methods of relationship matching and SNP analysis on an enlarged scale are used in a forensic setting to identify a suspect in a criminal investigation or a missing person. There is currently a strong need in forensic genetics not only to understand the underlying models to infer relatedness but also to fully explore the DNA technologies and data used in IGG. This review brings together many of the topics and examines their effectiveness and operational limits, while suggesting future directions for their forensic validation. We further investigated the methods used by the major direct-to-consumer (DTC) genetic ancestry testing companies as well as submitting a questionnaire where providers of forensic genetic genealogy summarized their operation/ services. Although most of the DTC market, and genetic genealogy in general, has undisclosed, proprietary algorithms we review the current knowledge where information has been discussed and published more openly.

Place, publisher, year, edition, pages
Elsevier Ireland Ltd , 2021. Vol. 52, article id 102474
Keywords [en]
Genetic genealogy; SNP microarrays; Whole-genome-sequencing; Familial searching; Identity by descent; Forensic DNA analysis; Crime investigation
National Category
Genetics
Identifiers
URN: urn:nbn:se:liu:diva-175404DOI: 10.1016/j.fsigen.2021.102474ISI: 000637213700006PubMedID: 33592389OAI: oai:DiVA.org:liu-175404DiVA, id: diva2:1548969
Available from: 2021-05-04 Created: 2021-05-04 Last updated: 2021-05-25Bibliographically approved

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