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Biocompatible Nanoparticles as a Platform for Enhancing Antitumor Efficacy of Cisplatin-Tetradrine Combination
Nanjing Univ, Peoples R China; Nanjing Univ, Peoples R China.
Nanjing Univ, Peoples R China.
Nanjing Univ, Peoples R China.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Children's and Women's Health. Linköping University, Faculty of Medicine and Health Sciences.
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2021 (English)In: Nanoscale Research Letters, ISSN 1931-7573, E-ISSN 1556-276X, Vol. 16, no 1, article id 61Article in journal (Refereed) Published
Abstract [en]

Combination therapy has been a standard strategy in the clinical tumor treatment. We have demonstrated that combination of Tetradrine (Tet) and Cisplatin (CDDP) presented a marked synergistic anticancer activity, but inevitable side effects limit their therapeutic concentration. Considering the different physicochemical and pharmacokinetic properties of the two drugs, we loaded them into a nanovehicle together by the improved double emulsion method. The nanoparticles (NPs) were prepared from the mixture of poly(ethyleneglycol)-polycaprolactone (PEG-PCL) and polycarprolactone (HO-PCL), so CDDP and Tet can be located into the NPs simultaneously, resulting in low interfering effect and high stability. Images from fluorescence microscope revealed the cellular uptake of both hydrophilic and hydrophobic agents delivered by the NPs. In vitro studies on different tumor cell lines and tumor tissue revealed increased tumor inhibition and apoptosis rates. As to the in vivo studies, superior antitumor efficacy and reduced side effects were observed in the NPs group. Furthermore, (18)FDG-PET/CT imaging demonstrated that NPs reduced metabolic activities of tumors more prominently. Our results suggest that PEG-PCL block copolymeric NPs could be a promising carrier for combined chemotherapy with solid efficacy and minor side effects.

Place, publisher, year, edition, pages
Springer, 2021. Vol. 16, no 1, article id 61
Keywords [en]
Copolymer; Nanoparticles; Combination therapy; Cisplatin; Tetradrine
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-175416DOI: 10.1186/s11671-021-03511-4ISI: 000640195800001PubMedID: 33855646OAI: oai:DiVA.org:liu-175416DiVA, id: diva2:1548990
Note

Funding Agencies|Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81972192, 81972309]; Primary Research & Development Plan of Jiangsu Province [BE2020619]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2020-211]

Available from: 2021-05-04 Created: 2021-05-04 Last updated: 2021-05-25Bibliographically approved

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