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Sphingolipids in HDL - Potential markers for adaptation to pregnancy?
Mahidol Univ, Thailand; Univ Glasgow, Scotland; Univ Glasgow, Scotland.
Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för prevention, rehabilitering och nära vård. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Medicincentrum, Arbets- och miljömedicin.
Erasmus MC, Netherlands.
Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för prevention, rehabilitering och nära vård. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Medicincentrum, Arbets- och miljömedicin.ORCID-id: 0000-0003-3984-3964
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2021 (engelsk)Inngår i: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, E-ISSN 1879-2618, Vol. 1866, nr 8, artikkel-id 158955Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Plasma high density lipoprotein (HDL) exhibits many functions that render it an effective endothelial protective agent and may underlie its potential role in protecting the maternal vascular endothelium during pregnancy. In non-pregnant individuals, the HDL lipidome is altered in metabolic disease compared to healthy individuals and is linked to reduced cholesterol efflux, an effect that can be reversed by lifestyle management. Specific sphingolipids such as sphingosine-1-phosphate (S1P) have been shown to mediate the vaso-dilatory effects of plasma HDL via interaction with the endothelial nitric oxide synthase pathway. This review describes the relationship between plasma HDL and vascular function during healthy pregnancy and details how this is lost in preeclampsia, a disorder of pregnancy associated with widespread endothelial dysfunction. Evidence of a role for HDL sphingolipids, in particular S1P and ceramide, in cardiovascular disease and in healthy pregnancy and pre-eclampsia is discussed. Available data suggest that HDL-S1P and HDL-ceramide can mediate vascular protection in healthy pregnancy but not in preeclampsia. HDL sphingolipids thus are of potential importance in the healthy maternal adaptation to pregnancy.

sted, utgiver, år, opplag, sider
Elsevier , 2021. Vol. 1866, nr 8, artikkel-id 158955
Emneord [en]
High density lipoprotein; Pregnancy; Preeclampsia; Sphingolipid; Sphingosine-1-phosphate; Ceramide; Vascular function
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-176822DOI: 10.1016/j.bbalip.2021.158955ISI: 000656122900011PubMedID: 33933650OAI: oai:DiVA.org:liu-176822DiVA, id: diva2:1569972
Merknad

Funding Agencies|Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand; BHF Centre of Research Excellence; Oxford BHF Centre of Research Excellence; University of Glasgow, College of Medical, Veterinary and Life Sciences [RE/13/5/30177]; NHSGGC Endowment Project [GN17OG441]

Tilgjengelig fra: 2021-06-21 Laget: 2021-06-21 Sist oppdatert: 2021-08-13

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