liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0002-8015-5728
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0001-9867-8706
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Onkologiskt centrum.
Karolinska University .
Vise andre og tillknytning
2009 (engelsk)Inngår i: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 104, nr 2, s. 130-137Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The purpose of this study was to evaluate the role of sequence variants in the CYP2C8, ABCB1 and CYP3A4 genes and the CYP3A4 phenotype for the pharmacokinetics and toxicity of paclitaxel in ovarian cancer patients. Thirty-eight patients were treated with paclitaxel and carboplatin. The genotypes of CYP2C8*1B, *1C, *2, *3, *4, *5, *6, *7, *8 and P404A, ABCB1 G2677T/A and C3435T, as well as CYP3A4*1B, were determined by pyrosequencing. Phenotyping of CYP3A4 was performed in vivo with quinine as a probe. The patients were monitored for toxicity and 23 patients underwent a more extensive neurotoxicity evaluation. Patients heterozygous for G/A in position 2677 in ABCB1 had a significantly higher clearance of paclitaxel than most other ABCB1 variants. A lower clearance of paclitaxel was found for patients heterozygous for CYP2C8*3 when stratified according to the ABCB1 G2677T/A genotype. In addition, the CYP3A4 enzyme activity in vivo affected which metabolic pathway was dominant in each patient, but not the total clearance of paclitaxel. The exposure to paclitaxel correlated to the degree of neurotoxicity. Our findings suggest that interindividual variability in paclitaxel pharmacokinetics might be predicted by ABCB1 and CYP2C8 genotypes and provide useful information for individualized chemotherapy.

sted, utgiver, år, opplag, sider
Wiley-Blackwell Publishing Inc., 2009. Vol. 104, nr 2, s. 130-137
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-16525DOI: 10.1111/j.1742-7843.2008.00351.xISI: 000262487400008PubMedID: 19143748Scopus ID: 2-s2.0-58449133201OAI: oai:DiVA.org:liu-16525DiVA, id: diva2:158136
Merknad

This is the authors’ version of the following article: Henrik Green, Peter Söderkvist, Per Rosenberg, Rajaa A Mirghani, Per Rymark, Elisabeth Avall Lundqvist and Curt Peterson, Pharmacogenetic Studies of Paclitaxel in the Treatment of Ovarian Cancer, 2009, Basic and clinical pharmacology and toxicology, (104), 2, 130-137. which has been published in final form at: http://dx.doi.org/10.1111/j.1742-7843.2008.00351.x Copyright: Blackwell Publishing http://eu.wiley.com/WileyCDA/Brand/id-35.html

Tilgjengelig fra: 2009-01-30 Laget: 2009-01-30 Sist oppdatert: 2021-12-28bibliografisk kontrollert

Open Access i DiVA

fulltekst(373 kB)1003 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 373 kBChecksum SHA-512
6ecd45f02bb318b2e89fe7a42b5b34febaefc4df9ce74aa3a0c2e158197229a510a90dea6ff39c56e969b5c9a60801ebed21fa37052cbcbb282373055d49d92d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Person

Green, HenrikSöderkvist, PeterRosenberg, PerÅvall Lundqvist, ElisabethPeterson, Curt

Søk i DiVA

Av forfatter/redaktør
Green, HenrikSöderkvist, PeterRosenberg, PerÅvall Lundqvist, ElisabethPeterson, Curt
Av organisasjonen
I samme tidsskrift
Basic & Clinical Pharmacology & Toxicology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 1004 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 576 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf