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Reorganization of large-scale brain networks in deaf signing adults: The role of auditory cortex in functional reorganization following deafness
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. (Linnaeus Centre HEAD)ORCID iD: 0000-0001-7091-9635
Linköping University, Department of Behavioural Sciences and Learning, Disability Research. Linköping University, Faculty of Arts and Sciences. Linköping University, Center for Medical Image Science and Visualization (CMIV). (Linnaeus Centre HEAD)ORCID iD: 0000-0002-1896-8250
2022 (English)In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 166, article id 108139Article in journal (Refereed) Published
Abstract [en]

If the brain is deprived of input from one or more senses during development, functional and structural reorganization of the deprived regions takes place. However, little is known about how sensory deprivation affects large-scale brain networks. In the present study, we use data-driven independent component analysis (ICA) to characterize large-scale brain networks in 15 deaf early signers and 24 hearing non-signers based on resting-state functional MRI data. We found differences between the groups in independent components representing the left lateralized control network, the default network, the ventral somatomotor network, and the attention network. In addition, we showed stronger functional connectivity for deaf compared to hearing individuals from the middle and superior temporal cortices to the cingulate cortex, insular cortex, cuneus and precuneus, supramarginal gyrus, supplementary motor area, and cerebellum crus 1, and stronger connectivity for hearing non-signers to hippocampus, middle and superior frontal gyri, pre- and postcentral gyri, and cerebellum crus 8. These results show that deafness induces large-scale network reorganization, with the middle/superior temporal cortex as a central node of plasticity. Cross-modal reorganization may be associated with behavioral adaptations to the environment, including superior ability in some visual functions such as visual working memory and visual attention, in deaf signers.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 2022. Vol. 166, article id 108139
Keywords [en]
Deaf signers, Deafness, Large-scale brain networks, ICA, Functional connectivity, Superior temporal cortex
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:liu:diva-182195DOI: 10.1016/j.neuropsychologia.2021.108139ISI: 000787600400008PubMedID: 34990695OAI: oai:DiVA.org:liu-182195DiVA, id: diva2:1626225
Funder
Swedish Research Council, 2015–00929Available from: 2022-01-11 Created: 2022-01-11 Last updated: 2023-02-17Bibliographically approved

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Andin, JosefineHolmer, Emil

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