liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain
Stazione Zool Anton Dohrn, Italy; Inst Mol Biol IMB, Germany.
Stazione Zool Anton Dohrn, Italy.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Cell Biology. Linköping University, Faculty of Medicine and Health Sciences. Stazione Zool Anton Dohrn, Italy; Ist Italiano Tecnol IIT, Italy.
Stazione Zool Anton Dohrn, Italy.
Show others and affiliations
2022 (English)In: BMC Biology, E-ISSN 1741-7007, Vol. 20, no 1, article id 116Article in journal (Refereed) Published
Abstract [en]

Background Transposable elements (TEs) widely contribute to the evolution of genomes allowing genomic innovations, generating germinal and somatic heterogeneity, and giving birth to long non-coding RNAs (lncRNAs). These features have been associated to the evolution, functioning, and complexity of the nervous system at such a level that somatic retrotransposition of long interspersed element (LINE) L1 has been proposed to be associated to human cognition. Among invertebrates, octopuses are fascinating animals whose nervous system reaches a high level of complexity achieving sophisticated cognitive abilities. The sequencing of the genome of the Octopus bimaculoides revealed a striking expansion of TEs which were proposed to have contributed to the evolution of its complex nervous system. We recently found a similar expansion also in the genome of Octopus vulgaris. However, a specific search for the existence and the transcription of full-length transpositionally competent TEs has not been performed in this genus. Results Here, we report the identification of LINE elements competent for retrotransposition in Octopus vulgaris and Octopus bimaculoides and show evidence suggesting that they might be transcribed and determine germline and somatic polymorphisms especially in the brain. Transcription and translation measured for one of these elements resulted in specific signals in neurons belonging to areas associated with behavioral plasticity. We also report the transcription of thousands of lncRNAs and the pervasive inclusion of TE fragments in the transcriptomes of both Octopus species, further testifying the crucial activity of TEs in the evolution of the octopus genomes. Conclusions The neural transcriptome of the octopus shows the transcription of thousands of putative lncRNAs and of a full-length LINE element belonging to the RTE class. We speculate that a convergent evolutionary process involving retrotransposons activity in the brain has been important for the evolution of sophisticated cognitive abilities in this genus.

Place, publisher, year, edition, pages
BMC , 2022. Vol. 20, no 1, article id 116
Keywords [en]
Mollusks; Nervous system; Transcriptome; Transposable elements
National Category
Other Biological Topics
Identifiers
URN: urn:nbn:se:liu:diva-185373DOI: 10.1186/s12915-022-01303-5ISI: 000796994000001PubMedID: 35581640OAI: oai:DiVA.org:liu-185373DiVA, id: diva2:1662351
Note

Funding Agencies|Progetto Premiale MolEcOC (Italian Ministry of Education, University and Research, MIUR); Flagship project RITMARE (MIUR and Stazione Zoologica); BIOforIU PON Project (MIUR); BIOforIU PON Project (European Regional Development Fund, FESR); SZN PhD fellowship

Available from: 2022-05-31 Created: 2022-05-31 Last updated: 2024-01-17

Open Access in DiVA

fulltext(3102 kB)93 downloads
File information
File name FULLTEXT01.pdfFile size 3102 kBChecksum SHA-512
11c679065f0bcf320e25119d3e633068369386dbb8a60c7a45fff760570e7a511f8dd12099ade0e5d57ba390b386dc108cb30d5309892ce586b140fba5607183
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Volpe, Massimiliano
By organisation
Division of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
BMC Biology
Other Biological Topics

Search outside of DiVA

GoogleGoogle Scholar
Total: 94 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 128 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf