The crack initiation life of a ductile additively manufactured nickel-based superalloy is studied and modeled for low-cycle fatigue and thermomechanical fatigue conditions up to 600 degrees C. Isothermal experiments were performed on smooth specimens at temperatures up to 600 degrees C with different applied strain ranges. Additionally, thermomechanical fatigue experiments at 100-450 degrees C and 100-600 degrees C were performed on smooth specimens under in-phase and out-of-phase conditions. A life prediction model accounting for the anisotropy was developed, where the temperature cycle is accounted with a Delta T$$ \Delta T $$-functionality, generating good agreements with the experiments. The model was also validated on notched specimens undergoing thermomechanical fatigue conditions at 100-500 degrees C using simplified notch correction methods.