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Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence
Linköping University, Department of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. NIDA, MD 21224 USA.
NIDA, MD USA.
NIDA, MD 21224 USA.
NIDA, MD USA.
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2023 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 9, no 2, article id eadd8687Article in journal (Refereed) Published
Abstract [en]

High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun020-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2023. Vol. 9, no 2, article id eadd8687
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Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-191360DOI: 10.1126/sciadv.add8687ISI: 000911464300027PubMedID: 36630511OAI: oai:DiVA.org:liu-191360DiVA, id: diva2:1732576
Note

Funding Agencies|Intramural Research Program of the NIDA-NIH [ZIA-DA000434-22]; Swedish Research Council International Postdoc grant [2019-00658]

Available from: 2023-01-31 Created: 2023-01-31 Last updated: 2023-02-20

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Citation style
  • apa
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  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
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  • Other locale
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Output format
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