liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Long-QT mutations in KCNE1 modulate the 1713-estradiol response of Kv7.1/KCNE1
Linköping University, Department of Biomedical and Clinical Sciences. Linköping University, Faculty of Medicine and Health Sciences.
Univ Hosp Bern, Switzerland; Univ Bern, Switzerland.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Department of Neurosurgery.ORCID iD: 0000-0003-3852-1015
Show others and affiliations
2023 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 9, no 11, article id eade7109Article in journal (Refereed) Published
Abstract [en]

Estradiol (1713-E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syn-drome (LQTS) compared to men. However, the underlying mechanisms remain poorly understood, and little is known about the impact of LQTS-associated mutations. We show that 1713-E2 inhibits the human cardiac Kv7.1/ KCNE1 channel expressed in Xenopus oocytes. We find that the 1713-E2 effect depends on the Kv7.1 to KCNE1 stoichiometry, and we reveal a critical function of the KCNE1 carboxyl terminus for the effect. LQTS-associated mutations in the KCNE1 carboxyl terminus show a range of responses to 1713-E2, from a wild-type like response to impaired or abolished response. Together, this study increases our understanding of the mechanistic basis for 1713-E2 inhibition of Kv7.1/KCNE1 and demonstrates mutation-dependent responses to 1713-E2. These findings suggest that the 1713-E2 effect on Kv7.1/KCNE1 might contribute to the higher arrhythmia risk of women, par-ticularly in carriers with specific LQTS-associated mutations.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2023. Vol. 9, no 11, article id eade7109
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:liu:diva-193598DOI: 10.1126/sciadv.ade7109ISI: 000968083500002PubMedID: 36921038OAI: oai:DiVA.org:liu-193598DiVA, id: diva2:1755981
Note

Funding Agencies|European Research Council under the European Unions Horizon 2020 research and innovation program [850622]

Available from: 2023-05-10 Created: 2023-05-10 Last updated: 2024-05-05

Open Access in DiVA

fulltext(1546 kB)222 downloads
File information
File name FULLTEXT01.pdfFile size 1546 kBChecksum SHA-512
ce9af36afc22950a8a15ad4e2b58158471aa7bc8e5c8191a8d2e6f56bf3ca393c8a66d4cecb439ac0154ed52a03271dda7761f9695ec979c58f9c94cec67b606
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records

Nikesjö, Johan

Search in DiVA

By author/editor
Erlandsdotter, Lisa-MarieHalili, AzemineNikesjö, JohanGreen, HenrikLiin, Sara
By organisation
Department of Biomedical and Clinical SciencesFaculty of Medicine and Health SciencesDivision of NeurobiologyDepartment of NeurosurgeryDivision of Clinical Chemistry and Pharmacology
In the same journal
Science Advances
Cell and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 222 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 246 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf