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Thinking versus feeling: How interoception and cognition influence emotion recognition in behavioural-variant frontotemporal dementia, Alzheimers disease, and Parkinsons disease
Univ Sydney, Australia; Univ Sydney, Australia.
Univ San Andres, Argentina; Natl Sci & Tech Res Council CONICET, Argentina; Univ Nacl Cordoba, Argentina; Univ Adolfo Ibanez, Chile.
Univ San Andres, Argentina.
Univ Sydney, Australia; Univ Sydney, Australia.
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2023 (English)In: Cortex, ISSN 0010-9452, E-ISSN 1973-8102, Vol. 163, p. 66-79Article in journal (Refereed) Published
Abstract [en]

Disease-specific mechanisms underlying emotion recognition difficulties in behavioural -variant frontotemporal dementia (bvFTD), Alzheimers disease (AD), and Parkinsons dis-ease (PD) are unknown. Interoceptive accuracy, accurately detecting internal cues (e.g., ones heart beating), and cognitive abilities are candidate mechanisms underlying emotion recognition.One hundred and sixty-eight participants (52 bvFTD; 41 AD; 24 PD; 51 controls) were recruited. Emotion recognition was measured via the Facial Affect Selection Task or the Mini-Social and Emotional Assessment Emotion Recognition Task. Interoception was assessed with a heartbeat detection task. Participants pressed a button each time they: 1) felt their heartbeat (Interoception); or 2) heard a recorded heartbeat (Exteroception-con-trol). Cognition was measured via the Addenbrookes Cognitive Examination-III or the Montreal Cognitive Assessment. Voxel-based morphometry analyses identified neural correlates associated with emotion recognition and interoceptive accuracy. All patient groups showed worse emotion recognition and cognition than controls (all Ps < .008). Only the bvFTD showed worse interoceptive accuracy than controls (P < .001). Regression analyses revealed that in bvFTD worse interoceptive accuracy predicted worse emotion recognition (P = .008). Whereas worse cognition predicted worse emotion recogni-tion overall (P < .001). Neuroimaging analyses revealed that the insula, orbitofrontal cortex, and amygdala were involved in emotion recognition and interoceptive accuracy in bvFTD. Here, we provide evidence for disease-specific mechanisms for emotion recognition difficulties. In bvFTD, emotion recognition impairment is driven by inaccurate perception of the internal milieu. Whereas, in AD and PD, cognitive impairment likely underlies emotion recognition deficits. The current study furthers our theoretical understanding of emotion and highlights the need for targeted interventions. (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Place, publisher, year, edition, pages
ELSEVIER MASSON, CORP OFF , 2023. Vol. 163, p. 66-79
Keywords [en]
Behavioural-variant frontotemporal; dementia; Interoception; Emotion; Social cognition; Insula
National Category
Applied Psychology
Identifiers
URN: urn:nbn:se:liu:diva-194446DOI: 10.1016/j.cortex.2023.02.009ISI: 000988752800001PubMedID: 37075507OAI: oai:DiVA.org:liu-194446DiVA, id: diva2:1764182
Note

Funding Agencies|ForeFront; National Health and Medical Research Council (NHMRC) [GNT1037746]; Australian Research Council grant [DP170101815]; Takeda [CW2680521]; CONICET; FONCYT-PICT [2017-1818, 2017-1820]; ANID/FONDECYT [1,210,195, 1,210,176, 1,220,995]; ANID/FONDAP [15,150,012]; ANID/PIA/ANILLOS [ACT210096]; Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) - National Institutes of Aging of the National Institutes of Health [R01AG057234]; Alzheimers Association grant [SG-20-725707-ReDLat]; Rainwater Foundation; Global Brain Health Institute; NHMRC Senior Research Fellowship [GNT1103258]; NHMRC Career Development Fellowship [GNT1158762]

Available from: 2023-06-08 Created: 2023-06-08 Last updated: 2023-10-26

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