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Nanocellulose Reinforced Hyaluronan-Based Bioinks
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering. (Laboratory of Molecular Materials)
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering. (Laboratory of Molecular Materials)ORCID iD: 0000-0002-8491-8155
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering. (Laboratory of Molecular Materials)ORCID iD: 0000-0002-2803-2237
Linköping University, Department of Physics, Chemistry and Biology, Biophysics and bioengineering. Linköping University, Faculty of Science & Engineering. (Laboratory of Molecular Materials)ORCID iD: 0000-0002-1781-1489
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2023 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 24, no 7, p. 3086-3093Article in journal (Refereed) Published
Abstract [en]

Bioprinting of hydrogel-based bioinks can allow for thefabricationof elaborate, cell-laden 3D structures. In addition to providing anadequate extracellular matrix mimetic environment and high cell viability,the hydrogels must offer facile extrusion through the printing nozzleand retain the shape of the printed structure. We demonstrate a strategyto incorporate cellulose oxalate nanofibrils in hyaluronan-based hydrogelsto generate shear thinning bioinks that allowed for printing of free-standingmultilayer structures, covalently cross-linked after bioprinting,yielding long-term stability. The storage modulus of the hydrogelswas tunable between 0.5 and 1.5 kPa. The nanocellulose containinghydrogels showed good biocompatibility, with viability of primaryhuman dermal fibroblasts above 80% at day 7 after seeding. The cellswere also shown to tolerate the printing process well, with viabilityabove 80% 24 h after printing. We anticipate that this hydrogel systemcan find broad use as a bioink to produce complex geometries thatcan support cell growth.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC , 2023. Vol. 24, no 7, p. 3086-3093
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:liu:diva-196800DOI: 10.1021/acs.biomac.3c00168ISI: 001016666500001PubMedID: 37341704OAI: oai:DiVA.org:liu-196800DiVA, id: diva2:1790804
Note

Funding Agencies|Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]; Carl Tryggers Foundation; Knut and Alice Wallenberg Foundation [KAW 2016.0231, 2021.0186]

Available from: 2023-08-23 Created: 2023-08-23 Last updated: 2024-01-11

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