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In vivo neuromodulation of animal behavior with organic semiconducting oligomers
CNR, Italy; Univ Zaragoza, Spain.
CNR, Italy.
CNR, Italy.
Linköping University, Department of Science and Technology, Laboratory of Organic Electronics. Linköping University, Faculty of Science & Engineering.ORCID iD: 0000-0001-5213-9002
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2023 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 9, no 42, article id eadi5488Article in journal (Refereed) Published
Abstract [en]

Modulating neural activity with electrical or chemical stimulus can be used for fundamental and applied research. Typically, neuronal stimulation is performed with intracellular and extracellular electrodes that deliver brief electrical pulses to neurons. However, alternative wireless methodologies based on functional materials may allow clinical translation of technologies to modulate neuronal function. Here, we show that the organic semiconducting oligomer 4-[2-{2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)thiophen-3-yl}ethoxy]butane-1-sulfonate (ETE-S) induces precise behaviors in the small invertebrate Hydra, which were dissected through pharmacological and electrophysiological approaches. ETE-S-induced behavioral response relies on the presence of head neurons and calcium ions and is prevented by drugs targeting ionotropic channels and muscle contraction. Moreover, ETE-S affects Hydras electrical activity enhancing the contraction burst frequency. The unexpected neuromodulatory function played by this conjugated oligomer on a simple nerve net opens intriguing research possibilities on fundamental chemical and physical phenomena behind organic bioelectronic interfaces for neuromodulation and on alternative methods that could catalyze a wide expansion of this rising technology for clinical applications.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE , 2023. Vol. 9, no 42, article id eadi5488
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Textile, Rubber and Polymeric Materials
Identifiers
URN: urn:nbn:se:liu:diva-199247DOI: 10.1126/sciadv.adi5488ISI: 001087790200011PubMedID: 37851802OAI: oai:DiVA.org:liu-199247DiVA, id: diva2:1813919
Note

Funding Agencies|Air Force Office of Scientific Research [FA8655-22-1-7014]; European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program "LINCE" [803621]; European Union (ERC-2021-STG, 4DPhytoHybrid) [101042148]; Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Available from: 2023-11-22 Created: 2023-11-22 Last updated: 2023-11-22

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Dufil, GwennaelStavrinidou, Eleni
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