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FK-means: automatic atrial fibrosis segmentation using fractal-guided K-means clustering with Voronoi-clipping feature extraction of anatomical structures
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences.
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences.ORCID iD: 0000-0001-6142-3005
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Diagnostics and Specialist Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Heart Center, Department of Clinical Physiology in Linköping. Linköping University, Center for Medical Image Science and Visualization (CMIV).ORCID iD: 0000-0003-2198-9690
2023 (English)In: Interface Focus, ISSN 2042-8898, E-ISSN 2042-8901, Vol. 13, no 6, article id 20230033Article in journal (Refereed) Published
Abstract [en]

Assessment of left atrial (LA) fibrosis from late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) adds to the management of patients with atrial fibrillation. However, accurate assessment of fibrosis in the LA wall remains challenging. Excluding anatomical structures in the LA proximity using clipping techniques can reduce misclassification of LA fibrosis. A novel FK-means approach for combined automatic clipping and automatic fibrosis segmentation was developed. This approach combines a feature-based Voronoi diagram with a hierarchical 3D K-means fractal-based method. The proposed automatic Voronoi clipping method was applied on LGE-MRI data and achieved a Dice score of 0.75, similar to the score obtained by a deep learning method (3D UNet) for clipping (0.74). The automatic fibrosis segmentation method, which uses the Voronoi clipping method, achieved a Dice score of 0.76. This outperformed a 3D UNet method for clipping and fibrosis classification, which had a Dice score of 0.69. Moreover, the proposed automatic fibrosis segmentation method achieved a Dice score of 0.90, using manual clipping of anatomical structures. The findings suggest that the automatic FK-means analysis approach enables reliable LA fibrosis segmentation and that clipping of anatomical structures in the atrial proximity can add to the assessment of atrial fibrosis.

Place, publisher, year, edition, pages
ROYAL SOC , 2023. Vol. 13, no 6, article id 20230033
Keywords [en]
fibrosis segmentation; left atrium; pulmonary veins; clipping; K-means; deep learning
National Category
Biophysics
Identifiers
URN: urn:nbn:se:liu:diva-199983DOI: 10.1098/rsfs.2023.0033ISI: 001125151500005PubMedID: 38106915OAI: oai:DiVA.org:liu-199983DiVA, id: diva2:1825863
Note

Funding Agencies|Swedish Heart and Lung Foundation

Available from: 2024-01-10 Created: 2024-01-10 Last updated: 2024-03-11

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Firouznia, MarjanHenningsson, MarkusCarlhäll, Carljohan
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Division of Diagnostics and Specialist MedicineFaculty of Medicine and Health SciencesDepartment of Clinical Physiology in LinköpingCenter for Medical Image Science and Visualization (CMIV)
In the same journal
Interface Focus
Biophysics
Firouznia, M., Henningsson, M. & Carlhäll, C.-J. (2023). Dataset and code for "FK-means: Automatic Atrial Fibrosis Segmentation using Fractal-guided K-means Clustering with Voronoi-Clipping Feature Extraction of Anatomical Structures": FKmeans for fibrosis segmentation. Linköping University Electronic Press

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