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The effects of opioid tapering on select endocrine measures in men and women with head and neck cancer-a longitudinal 12-month study
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.ORCID iD: 0000-0002-6640-0299
Linköping University, Department of Health, Medicine and Caring Sciences, Division of Prevention, Rehabilitation and Community Medicine. Linköping University, Faculty of Medicine and Health Sciences. Region Östergötland, Anaesthetics, Operations and Specialty Surgery Center, Pain and Rehabilitation Center.ORCID iD: 0000-0003-4420-418X
2024 (English)In: Pain Reports, E-ISSN 2471-2531, Vol. 9, no 5, article id e1183Article in journal (Refereed) Published
Abstract [en]

Introduction: Opioid treatment may affect endocrine measures in humans either through centrally or peripherally mediated mechanisms. There is a general lack of longitudinal studies examining endocrine measures in opioid-treated patients. Objectives: To longitudinally follow the levels of select endocrine measures in men and women with head and neck cancer for 1 year, who after having completed radiotherapy began tapering opioids. Methods: This was a prospective, longitudinal, observational study. Testosterone and estradiol were measured in men and women, respectively. Follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEAS), and prolactin were measured in both sexes. Women were grouped based on if premenopausal or postmenopausal. Samples were collected when opioid tapering started and at 1, 3, 6, and 12 months after tapering start. Daily opioid doses at the same time points were registered. Results: Twenty-five men and 12 women were followed for 12 months. In men, testosterone levels increased significantly during the first month after opioid tapering started (P < 0.001). Levels of testosterone, FSH, DHEAS, and prolactin changed significantly in men during the study period. A moderate correlation between opioid dose reduction and testosterone level increase in men aged <= 60 years was found (r(s) = -0.577, 95% CI -0.854 to -0.044, P = 0.039). In postmenopausal women (n = 10), levels of FSH and LH changed significantly during the study period. Conclusion: Previously known effects of opioids on endocrine measures in humans seem to be reversible as select endocrine measures changed significantly in men and postmenopausal women after opioid tapering was initiated.

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2024. Vol. 9, no 5, article id e1183
Keywords [en]
Opioid tapering; Opioid-induced hypogonadism; Endocrinopathy; Gonadal hormones; Testosterone; Cancer-related pain
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
URN: urn:nbn:se:liu:diva-207909DOI: 10.1097/PR9.0000000000001183ISI: 001311406500002PubMedID: 39285953Scopus ID: 2-s2.0-85204432066OAI: oai:DiVA.org:liu-207909DiVA, id: diva2:1901926
Note

Funding Agencies|Lions Post-doc Research Fund, Linkoping [LIU-2016-00641]; ALF Grants, Region Ostergotland [R O-962091]

Available from: 2024-09-30 Created: 2024-09-30 Last updated: 2025-02-11

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Kallman, Thomas F.Bäckryd, Emmanuel

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