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Obstetric, somatic, and demographic risk factors for postpartum depressive symptoms
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0003-3238-3811
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
Vise andre og tillknytning
2002 (engelsk)Inngår i: Obstetrics and gynecology, ISSN 0029-7844, Vol. 99, nr 2, s. 223-228Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To identify and test the predictive power of potential independent risk factors of postpartum depressive symptoms during pregnancy and the perinatal period.

METHODS: We conducted a case-control study where 132 women with postpartum depressive symptoms were selected as an index group and 264 women without depressive symptoms as a control group. Data related to sociodemographic status, medical, gynecologic, and obstetric history, pregnancy, and perinatal events were collected from standardized medical records.

RESULTS: The strongest risk factors for postpartum depressive symptoms were sick leave during pregnancy and a high number of visits to the antenatal care clinic. Complications during pregnancy, such as hyperemesis, premature contractions, and psychiatric disorder were more common in the postpartum depressed group of women. No association was found between parity, sociodemographic data, or mode of delivery and postpartum depressive symptoms.

CONCLUSION: Women at risk for postpartum depression can be identified during pregnancy. The strongest risk factors, sick leave during pregnancy and many visits to the antenatal care clinic, are not etiologic and might be of either behavioral or biologic origin. The possibilities of genetic vulnerability and hormonal changes warrant further investigation to reach a more thorough understanding.

sted, utgiver, år, opplag, sider
2002. Vol. 99, nr 2, s. 223-228
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-13668DOI: 10.1016/S0029-7844(01)01722-7OAI: oai:DiVA.org:liu-13668DiVA, id: diva2:21137
Tilgjengelig fra: 2003-04-30 Laget: 2003-04-30 Sist oppdatert: 2019-06-28
Inngår i avhandling
1. Postpartum Depression: Epidemiological and Biological Aspects
Åpne denne publikasjonen i ny fane eller vindu >>Postpartum Depression: Epidemiological and Biological Aspects
2003 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Postpartum depression is by definition a major depression with an onset during the first weeks after delivery. In practice, however, the term, postpartum depression is used to characterize all kinds of depressive symptoms after childbirth. The aims of this thesis were to investigate the prevalence of depressive symptoms during late pregnancy, in the puerperium and four years after delivery, and to analyze the mothers’ estimation of personal health and their children’s behavior at the age of four. Additional goals were to test the predictive power of potential associated factors of postpartum depression during pregnancy and the puerperium and finally, to elucidate possible genetic or neuropeptidergic explanatory variables behind the development of postpartum depression.

A population-based sample of 1489 women was screened with the Edinburgh Postnatal Depression Scale and the prevalence of depressive symptoms was 17% in late pregnancy and 13% postpartum. Antenatal depressed mood was related to postpartum depression. In a cross-sectional study we later found that postpartum depression was associated with subsequent depressive symptoms and current health problems four years after childbirth. Four-year-old boys of postpartum depressed mothers and children of mothers with a subsequent depressive status had more behavior problems than children of non-symptomatic mothers did, according to the mothers’ opinion.

The strongest associated factors for postpartum depression, in a case-control study, were sick leave during pregnancy mainly due to pregnancy complications, e.g. hyperemesis and premature contractions and a high number of visits to the antenatal care clinic. There was no association between delivery complications or complications in the perinatal period and postpartum depression. The theory that depressive symptoms in late pregnancy or postpartum are connected with CYP2D6 genotype could not be confirmed.

In a rat model, we found that pregnancy and parturition influence the concentrations of neuropeptide Y, cholecystokinin, substance P and galanin in the rat brain. This result supports the hypothesis that neuropeptidergic systems in the brain influence the mood changes around childbirth. In conclusion, postpartum depression is a common feature with influence on both maternal and child well being.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2003. s. 57
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 781
Emneord
Postpartum depression, pregnancy, childbirth, case-control study
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-5208 (URN)91-7373-537-X (ISBN)
Disputas
2003-04-11, Berzeliussalen, Campus US, Linköpings universitet, Linköping, 09:00 (engelsk)
Opponent
Veileder
Merknad
Pages 26 and 57 containing illustrations are removed from the electronic version. On the day of the public defence the status of article IV was: Accepted for publication.Tilgjengelig fra: 2003-04-30 Laget: 2003-04-30 Sist oppdatert: 2019-06-28bibliografisk kontrollert

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