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Iron Catalyzed Polymerization of Alkoxysulfonate-Functionalized EDOT gives
Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Organisk Kemi. Linköpings universitet, Tekniska högskolan.
Vise andre og tillknytning
2007 (engelsk)Inngår i: Chemistry of Materials, ISSN 0897-4756, E-ISSN 1520-5002Artikkel i tidsskrift (Fagfellevurdert) Submitted
sted, utgiver, år, opplag, sider
2007.
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-14604OAI: oai:DiVA.org:liu-14604DiVA, id: diva2:23997
Tilgjengelig fra: 2007-10-12 Laget: 2007-10-12 Sist oppdatert: 2017-12-13
Inngår i avhandling
1. Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires
Åpne denne publikasjonen i ny fane eller vindu >>Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires
2007 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The research field of conjugated polymers has grown due to the optical and electronic properties of the material, useful in applications such as solar cells and printed electronics, but also in biosensors and for interactions with biomolecules. In this thesis conjugated polymers have been used in two related topics; to detect conformational changes in proteins and to assemble the polymers with biomolecules into nanowires.

Within biosensing, conjugated polymers have been used for detection of a wide range of biological events, such as DNA hybridization or enzymatic activity, utilizing both electronic and optical changes in the polymer. Here the focus has been to use the polymers as optical probes to discriminate between native and misfolded protein, as well as to follow the misfolding processes in vitro. The understanding and detection of protein misfolding, for example amyloid fibril formation, is a topic of growing importance. The misfolding process is strongly associated with several devastating diseases such as Alzheimer’s disease, Parkinson’s disease and Bovine Spongiform Encephalopathy (BSE). We have developed detection schemes for discrimination between proteins in the native or amyloid fibril state based on luminescent polythiophene derivatives. Through a synthesis strategy based on polymerization of trimer blocks rather than of monomers, polythiophene derivatives with higher optical signal specificity for amyloid-like fibrils were obtained.

Self-assembly of nanowires containing conjugated polymers is a route to generate structures of unique opto-electrical characteristics without the need for tedious topdown processes. Biomolecules can have nanowire geometries of extraordinary aspect ratio and functionalities. The DNA molecule is the most well known and exploited of these. In this thesis work the more stable amyloid fibril has been used as a template to organize conjugated polymers. Luminescent, semi-conducting, conjugated polymers have been incorporated in and assembled onto amyloid fibrils. Using luminescence quenching we have demonstrated that the conjugated material can retain the electro-activity after the incorporation process. Furthermore, the amyloid fibril/conjugated polymer hybrid structures can be organized on surfaces by the means of molecular combing and soft lithography.

In the process of generating self-assembled biomolecular nanowires functionalized with conjugated polymers, we have shown a new synthesis strategy for a water-soluble highly conducting polythiophene derivative. This material, PEDOT-S, has shown affinity for amyloid fibrils, but can also be very useful in conventional opto-electronic polymer-based devices.

sted, utgiver, år, opplag, sider
Institutionen för fysik, kemi och biologi, 2007
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1117
Emneord
Conjugated Polymers, Amyloid Fibrils, Nanowires, Self-Assembly, Sensor, Amyloid Detection
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-9577 (URN)978-91-85831-42-5 (ISBN)
Disputas
2007-09-04, Planck, Physics Building, Linköping University, Linköping, 10:15 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2007-10-12 Laget: 2007-10-12 Sist oppdatert: 2020-03-24

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Karlsson, Roger H.Herland, AnnaHamedi, MahiarÅslund, AndreasInganäs, OlleKonradsson, Peter

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