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B vitamins improve health in patients with coeliac disease living on a gluten-free diet
Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Hälsa, Aktivitet, Vård (HAV). Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i östra Östergötland, Medicinkliniken ViN.
Värnamo Hospital.
Eksjö Hospital .
Lund University Hospital.
2009 (Engelska)Ingår i: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 29, nr 8, s. 811-816Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background Patients with coeliac disease living on a gluten-free diet show vitamin deficiency and reduced subjective health status.

Aim To study the biochemical and clinical effects of B vitamin supplementation in adults with longstanding coeliac disease.

Methods In a double blind placebo controlled multicentre trial, 65 coeliac patients (61% women) aged 45–64 years on a strict gluten-free diet for several years were randomized to a daily dose of 0.8 mg folic acid,0.5 mg cyanocobalamin and 3 mg pyridoxine or placebo for 6 months. The outcome measures were psychological general well-being (PGWB) and the plasma total homocysteine (tHcy) level, marker of B vitamin status.

Results Fifty-seven patients (88%) completed the trial. The tHcy level was baseline median 11.7 μmol/L (7.4–23.0), significantly higher than in matched population controls [10.2 μmol/L (6.7–22.6) (P < 0.01)]. Following vitamin supplementation, tHcy dropped a median of 34% (P < 0.001), accompanied by significant improvement in well-being (P < 0.01), notably Anxiety (P < 0.05) and Depressed Mood (P < 0.05) for patients with poor well-being.

Conclusions Adults with longstanding coeliac disease taking extra B vitamins for 6 months showed normalized tHcy and significant improvement in general well-being, suggesting that B vitamins should be considered in people advised to follow a gluten-free diet.

Ort, förlag, år, upplaga, sidor
2009. Vol. 29, nr 8, s. 811-816
Nyckelord [en]
Coeliac disease
Nationell ämneskategori
Gastroenterologi
Identifikatorer
URN: urn:nbn:se:liu:diva-20987DOI: 10.1111/j.1365-2036.2009.03945.xOAI: oai:DiVA.org:liu-20987DiVA, id: diva2:240272
Tillgänglig från: 2009-09-27 Skapad: 2009-09-27 Senast uppdaterad: 2017-12-13

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