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Paradigm design of sensory–motor and language tests in clinical fMRI
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-2167-2450
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiofysik. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Radiofysikavdelningen. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0001-8661-2232
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Neurologi. Östergötlands Läns Landsting, Närsjukvården i centrala Östergötland, Neurologiska kliniken. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.
2004 (Engelska)Ingår i: Neurophysiologie clinique, ISSN 0987-7053, E-ISSN 1769-7131, Vol. 34, nr 6, s. 267-277Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Functional magnetic resonance imaging (fMRI) paradigms on sensory–motor and language functions are reviewed from a clinical user’s perspective. The objective was to identify special requirements regarding the design of fMRI paradigms for clinical applications. A wide range of methods for setting up fMRI examinations were found in the literature. It was concluded that there is a need for standardised procedures adapted for clinical settings. Sensory–motor activation patterns do not vary much at different hand motion tasks. Nevertheless it is one of the most important clinical tests. In contrast, the language system is much more complex. In several studies it has been observed that word production tasks are preferable in determination of language lateralisation. Broca’s area is activated by most tasks, whereas sentence processing and semantic decision also involve activation in temporoparietal and frontal areas. However, combined task analysis (CTA) of several different tasks has been found to be more robust and reliable for clinical fMRI compared to separate task analysis.

Abstract [fr]

Les paradigmes utilisés en Imagerie par Résonance Magnétique fonctionnelle (IRMf) pour l’étude des fonctions sensori-motrice et du langage sont passés en revue du point de vue d’un clinicien. L’objectif était de souligner les exigences spéciales nécessaires à la mise en place d’un paradigme d’IRMf dans le cadre d’études cliniques. Un très grand nombre de procédures pour la réalisation d’examens en IRMf existent dans la littérature. Il a été mis en évidence que la mise en place de procédures standardisées, adaptées aux études cliniques était nécessaire. Les patterns d’activation sensori-motrice ne varient pas plus que les tâches de mouvements de la main. Néanmoins c’est l’un des tests les plus importants en pratique clinique. Au contraire, le système du langage est beaucoup plus complexe. Un grand nombre d’études ont montré que l’utilisation de tâches de production de mots était préférable pour étudier la latéralisation du langage. L’aire de Broca est activée par beaucoup de tâches, alors que le traitement des phrases et la décision sémantique entraînent une activation des aires frontales et temporopariétales. Cependant, dans un contexte d’IRMf clinique, l’analyse des tâches combinées de plusieurs tâches différentes est plus robuste et plus fiable que l’analyse des tâches séparées.

Ort, förlag, år, upplaga, sidor
2004. Vol. 34, nr 6, s. 267-277
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-24683DOI: 10.1016/j.neucli.2004.09.006ISI: 000228731600002Lokalt ID: 6919OAI: oai:DiVA.org:liu-24683DiVA, id: diva2:245005
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13
Ingår i avhandling
1. Application of fMRI in clinical situations
Öppna denna publikation i ny flik eller fönster >>Application of fMRI in clinical situations
2006 (Engelska)Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Since its discovery in the early 1990's functional MRI (fMRI) has become the most widely used technique for mapping of brain functions. Its non-invasiveness and the large number of MR-scanners have contributed to the popularity of fMRI. In recent years the interest in using fMRI as a clinical instrument has increased, primarily for pre-operative planning. The purpose of this work is to improve the applicability of fMRI to clinical situations.

In order to attain the objectives the capacity of analysis methods for fMRI was evaluated, design of paradigms to suit patients was looked into and the effects of an anxiolytic was investigated.

Especially when fMRI is used in the clinic it is crucial that the analysis method employed is sensitive and reliable. It was confirmed that the method developed by Friman et al. is a worthy competitor to other analysis methods. In general the abilities of patients are reduced compared with healthy volunteer subjects. Therefore one has to design the tasks and task instructions to be readily comprehensible. In addition it is not uncommon that patients are anxious before the examinations and the unfamiliar environment in the MR department. Some need a small dose of an anxiolytic to be able to undergo the examination. The effect of an anxiolytic on healthy volunteers was evaluated. No effects on the fMRI results was identified but the results were confounded by a large session effect.

Ort, förlag, år, upplaga, sidor
Linköping: Linköpings universitet, 2006. s. 83
Serie
Linköping Studies in Health Sciences. Thesis, ISSN 1100-6013 ; 76
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-36015 (URN)29386 (Lokalt ID)91-85497-79-7 (ISBN)29386 (Arkivnummer)29386 (OAI)
Presentation
2006-05-02, Wranne-salen, Hälsouniversitet, Linköping, 08:30 (Svenska)
Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2013-09-20

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Engström, MariaRagnehed, MattiasLundberg, PeterAxelsson Söderfeldt, Birgitta

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