liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Increasing Fecal Butyrate in Ulcerative Colitis Patients by Diet: Controlled Pilot Study
Linköpings universitet, Institutionen för vård och välfärd. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Närsjukvården i östra Östergötland, Medicinkliniken ViN.
Department of Applied Nutrition and Food Chemistry, Chemical Center, Lund University, Lund, Sweden.
Department of Applied Nutrition and Food Chemistry, Chemical Center, Lund University, Lund, Sweden.
Östergötlands Läns Landsting, Närsjukvården i östra Östergötland, Medicinkliniken ViN.
Vise andre og tillknytning
2003 (engelsk)Inngår i: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 9, nr 2, s. 116-121Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Topical butyrate has been shown to be effective in the treatment of ulcerative colitis (UC). Butyrate is derived from colonic fermentation of dietary fiber, and our aim was to study whether UC patients could safely increase the fecal butyrate level by dietary means. We enrolled 22 patients with quiescent UC (mean age, 44 years; 45% women; median time from last relapse, 1 year) in a controlled pilot trial lasting 3 months. The patients were instructed to add 60 g oat bran (corresponding to 20 g dietary fiber) to the daily diet, mainly as bread slices. Fecal short-chain fatty acids (SCFAs) including butyrate, disease activity, and gastrointestinal symptoms were recorded every 4 weeks. During the oat bran intervention the fecal butyrate concentration increased by 36% at 4 weeks (from 11 +/- 2 (mean +/- SEM) to 15 +/- 2 mumol/g feces) (p < 0.01). The mean butyrate concentration over the entire test period was 14 +/-1 &mu;mol/g feces (p < 0.05). Remaining fecal SCFA levels were unchanged. No patient showed signs of colitis relapse. Unlike controls, the patients showed no increase in gastrointestinal complaints during the trial. Yet patients reporting abdominal pain and reflux complaints at entry showed significant improvement at 12 weeks that returned to baseline 3 months later. This pilot study shows that patients with quiescent UC can safely take a diet rich in oat bran specifically to increase the fecal butyrate level. This may have clinical implications and warrants studies of the long-term benefits of using oat bran in the maintenance therapy in UC.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2003. Vol. 9, nr 2, s. 116-121
Emneord [en]
B-Glucans, butyrate, dietary fiber, nutrition, oat bran, prebiotics, SCFA, ulcerative colitis
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-24780DOI: 10.1097/00054725-200303000-00005ISI: 000181468100005Lokal ID: 7041OAI: oai:DiVA.org:liu-24780DiVA, id: diva2:245103
Tilgjengelig fra: 2009-10-07 Laget: 2009-10-07 Sist oppdatert: 2017-12-13bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Hallert, Claes

Søk i DiVA

Av forfatter/redaktør
Hallert, Claes
Av organisasjonen
I samme tidsskrift
Inflammatory Bowel Diseases

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 290 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf