liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Prostate cancer and exposure to pesticides in agricultural settings
Linköpings universitet, Institutionen för molekylär och klinisk medicin, Yrkes- och miljömedicin. Linköpings universitet, Hälsouniversitetet.
Local Health Unit, Imola, Italy.
Martini Hospital, Turin, Italy.
Linköpings universitet, Institutionen för molekylär och klinisk medicin, Yrkes- och miljömedicin. Linköpings universitet, Hälsouniversitetet.
2003 (Engelska)Ingår i: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 104, nr 4, s. 458-461Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Our study evaluates the association between prostate cancer and exposure to pesticides in agricultural settings in Italy. The data were derived from a hospital-based multi-site case-control study carried out in 5 rural areas between 1990–92. In our study, 124 new cases of prostate cancer were ascertained and interviewed, along with 659 cancer controls. A team of agronomists assessed past exposure to pesticides by using a checklist of 100 chemical families and 217 compounds applied from 1950–85 in the areas considered. The association between prostate cancer and different occupational risk factors was measured by maximum likelihood estimation of the odds ratio, controlling for potential confounders. “Ever been employed in agriculture” was associated with a 40% increased risk (OR = 1.4, 95% CI = 0.9–2.0). Prostate cancer was also related positively to food and tobacco (OR= 2.1, 95% CI = 1.1–4.1), and chemical products (OR = 2.2, 95% CI = 0.7–7.2) industries. The analyses carried out to estimate the association between different types of pesticides and prostate cancer showed increased risks among farmers exposed to organochlorine insecticides and acaricides (OR = 2.5, 95% CI = 1.4–4.2), more specifically to the often contemporary used compounds DDT (OR = 2.1, 95% CI = 1.2–3.8), and dicofol (OR = 2.8, 95% CI = 1.5–5.0), whose effects could not be well separated.

Ort, förlag, år, upplaga, sidor
2003. Vol. 104, nr 4, s. 458-461
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-26372DOI: 10.1002/ijc.10955Lokalt ID: 10906OAI: oai:DiVA.org:liu-26372DiVA, id: diva2:246921
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Ingår i avhandling
1. Cancer risks and immunological effects in agriculture
Öppna denna publikation i ny flik eller fönster >>Cancer risks and immunological effects in agriculture
2003 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

In general, farmers and agricultural workers are characterized by relatively low mortality rates when considering all causes of death and deaths due to all types of cancer. However, several studies have shown that this occupational category tend to be at increased risks of developing the following forms of malignancies: leukaemia, lymphomas, multiple myeloma, and cancers of the skin, lip, prostate, stomach, brain, and connective tissue. Although the reported excesses have not been consistent in different studies, they nevertheless suggest that agricultural exposures, especially pesticides, contribute to cancer aetiology through different mechanisms of action. It has been hypothesised that immunotoxic effects may play a role, since most of the malignancies found to be increased in workers employed in agriculture are also elevated in patients suffering from innnunodeficiencies. The present studies were conducted to ascertain whether agricultural activities and exposures influence the risk of developing cancer, and to evaluate the innnunological effects of phenoxy herbicides as possibly important for the aetiology of lymphomas.

Different types of cancer were considered in relation to farming in two case-control studies, focused one on men and the other on women. A decreased risk of postmenopausal breast cancer (odds ratio [OR] 0.4) and an excess of skin melanoma (OR 2.7) and bladder cancer (OR 2.7) were observed in the women. The main finding in the men was an excess of prostate cancer (OR 1.5). Further analyses showed that this malignancy was associated with exposure to chlorinated compounds (OR 2.5), and, more specifically, to DDT (OR 2.1) and dicofol and tetradifon (OR 2.8).

Mortality in selected groups of farmers and their relatives was investigated in two cohort studies. Farmers and their wives showed reduced mortality from all causes and all cancers although there was a tendency towards increased risk of leukaemia, particularly among wives of pesticide users (standardised mortality ratio [SMR] 2.4). Adult sons and daughters of green-house owners exhibited increased mortality from all types of cancer (SMR 1.9).

A study was also performed to compare pre- and post-exposure values of selected immunological parameters in a group of ten farmers exposed to phenoxy herbicides. The most notable fmdings were reduced levels of the following: circulating natural killer (NK) cells (-38%), NK cytotoxic activity (-53%), and lymphocyte response to mitogenic stimulation (-50%).

Ort, förlag, år, upplaga, sidor
Linköping: Linköpings universitet, 2003. s. 49
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 779
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-26668 (URN)11234 (Lokalt ID)91-7373-538-8 (ISBN)11234 (Arkivnummer)11234 (OAI)
Disputation
2003-04-08, Aulan, Hälsans hus, Universitetssjukhuset, Linköping, 13:00 (Svenska)
Opponent
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2012-10-15Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Personposter BETA

Axelson, Olav

Sök vidare i DiVA

Av författaren/redaktören
Axelson, Olav
Av organisationen
Yrkes- och miljömedicinHälsouniversitetet
I samma tidskrift
International Journal of Cancer
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 54 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf