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Phenotypes indicating cytolytic properties of Borrelia-specific interferon-? secreting cells in chronic Lyme neuroborreliosis
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Klinisk immunologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk immunologi och transfusionsmedicin.ORCID-id: 0000-0002-3993-9985
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Klinisk immunologi.
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2003 (engelsk)Inngår i: Journal of Neuroimmunology, ISSN 0165-5728, E-ISSN 1872-8421, Vol. 145, nr 1-2, s. 115-126Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The immuno-pathogenetic mechanisms underlying chronic Lyme neuroborreliosis are mainly unknown. Human Borrelia burgdorferi (Bb) infection is associated with Bb-specific secretion of interferon-? (IFN-?), which may be important for the elimination of Bb, but this may also cause tissue injury. In order to increase the understanding of the pathogenic mechanisms in chronic neuroborreliosis, we investigated which cell types that secrete IFN-?. Blood mononuclear cells from 13 patients with neuroborreliosis and/or acrodermatitis chronicum atrophicans were stimulated with Bb antigen and the phenotypes of the induced IFN-?-secreting cells were analyzed with three different approaches. Cells expressing CD8 or TCR?d, which both have cytolytic properties, were the main phenotypes of IFN-?-secreting cells, indicating that tissue injury in chronic neuroborreliosis may be mediated by cytotoxic cells.

sted, utgiver, år, opplag, sider
2003. Vol. 145, nr 1-2, s. 115-126
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Identifikatorer
URN: urn:nbn:se:liu:diva-26423DOI: 10.1016/j.jneuroim.2003.08.037Lokal ID: 10965OAI: oai:DiVA.org:liu-26423DiVA, id: diva2:246972
Tilgjengelig fra: 2009-10-08 Laget: 2009-10-08 Sist oppdatert: 2020-01-16

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Ekerfelt, ChristinaJarefors, SaraForsberg, PiaErnerudh, Jan

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