liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Estimation of relative cardiovascular pressures using time-resolved three-dimensional phase contrast MRI
Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0003-1395-8296
Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
Department of Medicine, University of California−San Francisco, San Francisco, CA.
Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
Visa övriga samt affilieringar
2001 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 45, nr 5, s. 872-879Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Accurate, easy-to-use, noninvasive cardiovascular pressure registration would be an important addition to the diagnostic armamentarium for assessment of cardiac function. A novel noninvasive and three-dimensional (3D) technique for estimation of relative cardiovascular pressures is presented. The relative pressure is calculated using the Navier-Stokes equations along user-defined lines placed within a time-resolved 3D phase contrast MRI dataset. The lines may be either straight or curved to follow an actual streamline. The technique is validated in an in vitro model and tested on in vivo cases of normal and abnormal transmitral pressure differences and intraaortic flow. The method supplements an intuitive visualization technique for cardiovascular flow, 3D particle trace visualization, with a quantifiable diagnostic parameter estimated from the same dataset.

Ort, förlag, år, upplaga, sidor
2001. Vol. 45, nr 5, s. 872-879
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-26700DOI: 10.1002/mrm.1116Lokalt ID: 11290OAI: oai:DiVA.org:liu-26700DiVA, id: diva2:247250
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2017-12-13
Ingår i avhandling
1. Cardiovascular fluid dynamics: methods for flow and pressure field analysis from magnetic resonance imaging
Öppna denna publikation i ny flik eller fönster >>Cardiovascular fluid dynamics: methods for flow and pressure field analysis from magnetic resonance imaging
2001 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Cardiovascular blood flow is highly complex and incompletely understood. Blood flow patterns are expected to influence the opening and closing of normal and prosthetic heart valves, the efficiency of cardiac filling and ejection, and the resistance to thrombus formation within the heart. Conventional diagnostic techniques are poorly suited to the study of the three-dimensional (3D) blood flow patterns in the heart chambers and large vessels. Noninvasive methods have also been inadequate in studying intracardiac pressure differences, which are the driving force of flow and are critical in the evaluation of many cardiovascular abnormalities.

This thesis focuses on the development of non-invasive methods for analysis of 3D cardiovascular blood flow. Simultaneous study of cardiovascular fluid dynamics allowed knowledge exchange across the two disciplines, facilitating the development process and broadening the applicability of the methods.

A time-resolved 3D phase-contrast Magnetic Resonance lrnaging (MRI) technique was used to acquire the velocity vector field in a 3D volume encompassing the entire heart or a large vessel. Cardiovascular blood flow patterns were visualized by use of particle traces, which revealed, for instance, vortical flow patterns in the left atrium.

By applying the Navier-Stokes equation along a user-defined line in the 3D velocity vector field, the relative pressure could be obtained as an excellent supplement to the flow pattern visualization. Using a delineation of the blood pool, the time-varying 3D relative pressure field in the human left ventricle was obtained from the velocity field by use of the pressure Poisson equation.

A delineation of the heart muscle, a task that is almost impossible to perform on 3D MRI either automatically or manually, was also achieved by usage of particle traces. This segmentation allows automatic calculation of the 3D relative pressure field, as well as calculation of well-established parameters such as ventricle volume and mass.

Simultaneous 3D assessment of cardiovascular pressure and flow phenomena throughout the cardiac cycle offers an opportunity to expand our understanding of the basic determinants of time-varying flow in healthy and sick hearts, with the potential for improving our methods for diagnosis, medical treatment and surgical correction of cardiovascular diseases.

Ort, förlag, år, upplaga, sidor
Linköping: Linköpings universitet, 2001. s. 48
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 690
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-28144 (URN)12957 (Lokalt ID)91-7373-021-1 (ISBN)12957 (Arkivnummer)12957 (OAI)
Disputation
2001-05-23, Elsa Brändströmssalen, Universiterssjukhuset, Linköping, 10:15 (Svenska)
Opponent
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2013-09-03

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Personposter BETA

Ebbers, TinoWigström, LarsEngvall, JanKarlsson, Matts

Sök vidare i DiVA

Av författaren/redaktören
Ebbers, TinoWigström, LarsEngvall, JanKarlsson, Matts
Av organisationen
Institutionen för medicinsk teknikTekniska högskolanKlinisk fysiologiHälsouniversitetet
I samma tidskrift
Magnetic Resonance in Medicine
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 606 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf