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Cholecystokinin peptides in cerebrospinal fluid: a study in healthy male subjects lumbar-punctured without preceding strict bed-rest
Department of Clinical Neuroscience and Family Medicine, Psychiatric Section, Karolinska Institute, Huddinge Hospitel, Sweden.
Department of Clinical Neuroscience and Family Medicine, Psychiatric Section, Karolinska Institute, Huddinge Hospitel, Sweden.
Department of Internal Medicine, Karolinska Institute, Huddinge Hospitel, Sweden.
Department of Internal Medicine, Karolinska Institute, Huddinge Hospitel, Sweden.
Vise andre og tillknytning
1999 (engelsk)Inngår i: Journal of neural transmission, ISSN 0300-9564, E-ISSN 1435-1463, Vol. 106, nr 3-4, s. 275-282Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In a recent study we analysed the concentrations of two forms of cholecystokinin (CCK), CCK-8S (sulphated) and CCK-4 in cerebrospinal fluid (CSF) obtained from 14 healthy male volunteers lumbar-punctured after a minimum of eight hours of strict bed-rest.

We have now lumbar-punctured another group of 14 healthy males, using the same procedure except for the requirement of strict bed-rest prior to puncture.

In contrast to our previous study, the concentration of CCK-4 (but not CCK-8S) was significantly higher in the second CSF fraction (7–12 ml) than in the first one (0–6 ml). On using the concentration ratio between the second and first fraction, CCK-8S (but not CCK-4) correlated positively with the atmospheric pressure, which is in contrast to our previous study in which a significant negative correlation was found.

When the lumbar CSF concentrations were expressed as the concentration per minute of tapping-time (an estimate of the mass flow), atmospheric pressure, age and the neuraxis distance in the lying position made significant contributions to the variance in CCK-8S. A significant positive correlation with atmospheric pressure was found for CCK-4.

In conclusion, the results indicate that the question of strict bed-rest or not prior to lumbar puncture may have to be considered when interpreting data on lumbar CSF concentrations of CCK. A controlled study is warranted.

sted, utgiver, år, opplag, sider
1999. Vol. 106, nr 3-4, s. 275-282
Emneord [en]
CCK-4, CCK-8, cerebrospinal fluid, atmospheric pressure
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-27799DOI: 10.1007/s007020050157Lokal ID: 12546OAI: oai:DiVA.org:liu-27799DiVA, id: diva2:248351
Tilgjengelig fra: 2009-10-08 Laget: 2009-10-08 Sist oppdatert: 2017-12-13bibliografisk kontrollert
Inngår i avhandling
1. On the cerebrospinal fluid disposition and neurobiological role of cholecystokinin in man
Åpne denne publikasjonen i ny fane eller vindu >>On the cerebrospinal fluid disposition and neurobiological role of cholecystokinin in man
2000 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Cholecystokinin (CCK) is the most abundant neuropeptide in the brain, where it acts as a neurotransmitter and neuromodulator. The tetrapeptide CCK-4 and the octapeptide CCK-8 have been implicated in various behavioural and physiological functions, such as anxiety, pain and satiety. Analyses of the levels of CCK in plasma, CSF and brain tissue have been used in studies aimed at elucidating the pathophysiological mechanisms in psychiatric disorders, but the results have been inconsistent.

Cerebrospinal fluid (CSF) levels of CCK-4 and CCK-8S were analysed in three groups of healthy subjects lumbar-punctured under different conditions, with the aim to provide reference values for studies on patients, and to investigate putative confounding factors. It was found that the concentrations of CCK-4 and CCK-8S were influenced by age, bedrest or not prior to lumbar puncture, neuraxis distance, position during lumbar puncture, height, atmospheric pressure and storage time. For a correct interpretation of data, these factors should be taken into account in future CSF studies in volunteers and patients.

Hypothyroidism is associated with depression. Thyroid hormones have been assumed to affect neuronal functions in the CNS, and animal experiments have indicated a relationship between thyroid hormones and CCK. Depressive symptoms were assessed in hypothyroid patients who were also lumbar-punctured before and during L-thyroxine treatment. Thyroid stimulating hormone, tri-iodothyronine and thyroxine in serum correlated with both CCK peptides in the CSF. A negative correlation between CCK-4 and inner tension (anxiety) was found.

Various studies implicate the involvement of brain-stem structures in the aetiology of panic attacks. Brain-stem auditory evoked potentials were recorded in healthy subjects before and during infusion with the panic-provoking agent CCK-4 or placebo. CCK-4 delayed the latencies of peak I, III and V, and decreased peak III amplitude. This suggests that exogenous CCK-4 affects stimulus processing in the brain stem.

sted, utgiver, år, opplag, sider
Linköping: Linköpings universitet, 2000. s. 70
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 643
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-28039 (URN)12800 (Lokal ID)91-7219-744-7 (ISBN)12800 (Arkivnummer)12800 (OAI)
Disputas
2000-10-20, Berzeliussalen, Hälsouniversitetet, Linköping, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2009-10-08 Laget: 2009-10-08 Sist oppdatert: 2012-08-14bibliografisk kontrollert

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