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Liver vessel enhancement by Gd-BOPTA and Gd-EOB-DTPA- a comparison in healthy volunteers
Department of Radiology, CLINTEC, Stockholm, Sweden.
Linköpings universitet, Institutionen för medicin och vård. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Department of Radiology, Hudiksvall Hospital, Sweden.ORCID-id: 0000-0002-4111-1693
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiologi. Östergötlands Läns Landsting, Bildmedicinskt centrum, Avdelningen för radiologi US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-7750-1917
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Medicinsk radiologi. Östergötlands Läns Landsting, Bildmedicinskt centrum, Avdelningen för radiologi US. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV.ORCID-id: 0000-0002-9446-6981
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2006 (Engelska)Ingår i: ISMRM 2006,2006, 2006Konferensbidrag, Publicerat paper (Övrigt vetenskapligt)
Ort, förlag, år, upplaga, sidor
2006.
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-34967Lokalt ID: 24315OAI: oai:DiVA.org:liu-34967DiVA, id: diva2:255815
Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2014-06-27
Ingår i avhandling
1. Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI
Öppna denna publikation i ny flik eller fönster >>Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI
2010 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients.

Ten healthy volunteers were examined with both contrast agents in a 1.5 T MRI system using three-dimensional gradient echo sequences for dynamic imaging until five hours after injection. The enhancement of the common hepatic duct in contrast to the liver parenchyma was analyzed in the first study. This was followed by a study of the image contrasts of the hepatic artery, portal vein and middle hepatic vein versus the liver parenchyma.

While Gd-EOB-DTPA gave an earlier and more prolonged enhancement and image contrast of the bile duct, Gd-BOPTA achieved higher maximal enhancement and higher image contrast for all vessels studied during the arterial and portal venous phases. There was no significant difference in the maximal enhancement obtained in the liver parenchyma.

In a third study, another 10 healthy volunteers were examined with the same protocol in another 1.5 T MRI system. Using signal normalization and a more quantitative, pharmacokinetic analysis, the hepatocyte-specific uptake of Gd-EOB-DTPA and Gd-BOPTA was calculated. A significant between-subjects correlation of the uptake estimates was found and the ratio of these uptake rates was of the same magnitude as has been reported in pre-clinical studies. The procedure also enabled quantitative analysis of vascular enhancement properties of these agents. Gd-BOPTA was found to give higher vessel-to-liver contrast than Gd-EOB-DTPA when recommended doses were given.

In the final study, retrospectively gathered datasets from patients with hepatobiliary disease were analyzed using the quantitative estimation of hepatic uptake of Gd-EOB-DTPA described in the third study. The uptake rate estimate provided significant predictive ability in separating normal from disturbed hepatobiliary function, which is promising for future evaluations of regional and global liver disease.

In conclusion, the differing dynamic enhancement profiles of the liver-specific contrast agents presented here can be beneficial in one context and challenging in another. Diseases of the liver and biliary system may affect the vasculature, parenchyma or biliary excretion, or a combination of these. The clinical context in terms of the relative importance of vascular, hepatic parenchymal and biliary processes should therefore determine the contrast agent for each patient and examination. A quantitative approach to analysis of contrast-enhanced liver MRI examinations is feasible and may prove valuable for their interpretation.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2010. s. 93
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1196
Nyckelord
Liver, spleen, hepatobiliary system, liver function, MRI, DCE-MRI, Gd-EOBDTPA, Gd-BOPTA, pharmacokinetic, hepatocyte, relaxivity.
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-60264 (URN)978-91-7393-338-4 (ISBN)
Disputation
2010-11-05, Elsa Brändströmsalen, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 09:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2010-10-08 Skapad: 2010-10-08 Senast uppdaterad: 2020-02-26Bibliografiskt granskad

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Dahlström, NilsSmedby, ÖrjanPersson, Anders

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Institutionen för medicin och vårdCentrum för medicinsk bildvetenskap och visualisering, CMIVHälsouniversitetetMedicinsk radiologiAvdelningen för radiologi US
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