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Mitochondrial damage and intralysosomal degradation in cellular aging
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Geriatrik.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Patologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk patologi och klinisk genetik.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Farmakologi.
2006 (engelsk)Inngår i: Molecular Aspects of Medicine, ISSN 0098-2997, E-ISSN 1872-9452, Vol. 27, nr 5-6, s. 471-482Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Normal mitochondrial respiration is associated with a continuous production of superoxide and hydrogen peroxide, inevitably resulting in minor macromolecular damage. Damaged cellular components are not completely turned over by autophagy and other cellular repair systems, leading to a progressive age-related accumulation of biological "garbage" material, such as defective mitochondria, cytoplasmic protein aggregates and an intralysosomal undegradable material, lipofuscin. These changes primarily affect neurons, cardiac myocytes and other long-lived postmitotic cells that neither dilute this "garbage" by mitotic activity, nor are replaced by newly differentiated cells. Defective mitochondria are insufficient in ATP production and often generate increased amounts of reactive oxygen species, further enhancing oxidative stress. Lipofuscin-loaded lysosomes, in turn, poorly turn over mitochondria that gradually leads to the overload of long-lived postmitotic cells with "garbage" material, decreased adaptability and eventual cell death. © 2006 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
2006. Vol. 27, nr 5-6, s. 471-482
Emneord [en]
Aging; Autophagocytosis; Lysosomes; Mitochondria; Oxidative stress
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-36022DOI: 10.1016/j.mam.2006.08.006Lokal ID: 29446OAI: oai:DiVA.org:liu-36022DiVA, id: diva2:256870
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2017-12-13

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Terman, AlexeiGustafsson, BertilBrunk, Ulf

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