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Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för biomedicin och kirurgi, Onkologi.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för nervsystem och rörelseorgan, Patologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk patologi och klinisk genetik.ORCID-id: 0000-0003-4075-159X
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för biomedicin och kirurgi, Onkologi. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Onkologiska kliniken US.
2006 (engelsk)Inngår i: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 231, nr 1, s. 113-122Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERα and ERβ. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERα- ERβ+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers. © 2005 Elsevier Ireland Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
2006. Vol. 231, nr 1, s. 113-122
Emneord [en]
Angiogenesis; Apoptosis; MDA-MB-231; Vascular endothelial growth factor, VEGF
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-36627DOI: 10.1016/j.canlet.2005.01.031Lokal ID: 31928OAI: oai:DiVA.org:liu-36627DiVA, id: diva2:257476
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2017-12-13

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