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Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens
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2006 (Engelska)Ingår i: British Journal of Haematology, ISSN 0007-1048, E-ISSN 1365-2141, Vol. 135, nr 3, s. 367-373Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted, 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations. © 2006 The Authors.

Ort, förlag, år, upplaga, sidor
2006. Vol. 135, nr 3, s. 367-373
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-37788DOI: 10.1111/j.1365-2141.2006.06302.xLokalt ID: 38627OAI: oai:DiVA.org:liu-37788DiVA, id: diva2:258637
Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13

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Malm, Claes

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