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Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för datavetenskap. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet.
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2008 (engelsk)Inngår i: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 108, nr 1, s. 35-41Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In situ synthesis of estrogens is believed to be of great importance for the progression of breast cancer. In postmenopausal women most estrogens are synthesized in peripheral hormone-target tissues from circulating precursor steroids, by the enzymes involved in formation of active estrogens. One of the enzymes involved in this process is 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1. This enzyme catalyzes the interconversion of estrone (E1) to the biologically more potent estradiol (E2). The gene coding for 17β-HSD type 1 (HSD17B1) is located at 17q12-21. The aim of this study was to investigate altered gene copy number of HSD17B1 in breast cancer. We used real-time PCR and examined 387 postmenopausal breast tumors for amplification of HSD17B1, and if an increased mRNA level of this enzyme is associated with amplification of the gene. We also investigated whether amplification of HSD17B1 has a prognostic value. There was a significant correlation between gene copy number of HSD17B1 and mRNA expression level (P = 0.00002). ER-positive patients with amplification of HSD17B1 showed lower breast cancer survival than patients without amplification (P = 0.025). Among ER-negative patients there was no significant correlation between increased gene copy number of HSD17B1 and prognosis. Furthermore, we found that amplification of the gene had prognostic significance in multivariate analysis adjusting for other clinicopathological variables. © 2007 Springer Science+Business Media, LLC.

sted, utgiver, år, opplag, sider
2008. Vol. 108, nr 1, s. 35-41
Emneord [en]
Breast Neoplasms/*genetics/mortality Disease-Free Survival Estradiol Dehydrogenases/*genetics Female *Gene Amplification Humans Kaplan-Meiers Estimate Middle Aged Postmenopause Prognosis RNA, Messenger/analysis Receptors, Estrogen/metabolism Reverse Trans
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URN: urn:nbn:se:liu:diva-43344DOI: 10.1007/s10549-007-9579-7Lokal ID: 73588OAI: oai:DiVA.org:liu-43344DiVA, id: diva2:264203
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2017-12-13bibliografisk kontrollert

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Forlagets fullteksthttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17457667

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Gunnarsson, CeciliaJerevall, Piiha-LottaHammar, KarlOlsson, BirgitNordenskjöld, BoJansson, AgnetaStål, Olle

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