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Randomized clinical trial of groin hernia repair with titanium-coated lightweight mesh compared with standard polypropylene mesh
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet.
Department of Surgery, Södertälje Hospital, Sweden.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
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2008 (engelsk)Inngår i: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 95, nr 10, s. 1226-1231Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Groin hernia repair is one of the commonest operations in general surgery. Existing techniques have very low and acceptable recurrence rates, but chronic pain and discomfort remain a problem for many patients. New mesh materials are being developed to increase biocompatibility, and the aim of this study was to compare a new titanium-coated lightweight mesh with a standard polypropylene mesh.

Methods: A randomized controlled single-centre clinical trial was designed, with the basic principle of one unit, one surgeon, one technique (Lichtenstein under general anaesthesia) and two meshes. Pain before and after surgery, and during convalescence (primary outcomes) was estimated in 317 patients. At 1-year clinical follow-up, recurrence, pain, discomfort and quality of life (secondary outcomes) were evaluated.

Results: Patients with the lightweight mesh returned to work after 4 days, compared with 6.5 days for the standard mesh (P = 0.040). The lightweight group returned to normal activity after 7 days, versus 10 days for the standard group (P = 0.005). There was no difference in postoperative pain or recurrence at the 1-year follow-up.

Conclusion: Patients with the lightweight mesh had a shorter convalescence than those with the standard heavyweight mesh. Registration number: ISRCTN36979348 (http://www.controlled-trials.com). Copyright © 2008 British Journal of Surgery Society Ltd Published by John Wiley & Sons Ltd.

sted, utgiver, år, opplag, sider
2008. Vol. 95, nr 10, s. 1226-1231
Emneord [en]
Adult Aged Hernia, Inguinal/*surgery Humans Male Middle Aged Pain Measurement Pain, Postoperative/etiology Polypropylenes/*therapeutic use Quality of Life Recurrence *Surgical Mesh Titanium/*administration & dosage Treatment Outcome
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-43370DOI: 10.1002/bjs.6325Lokal ID: 73656OAI: oai:DiVA.org:liu-43370DiVA, id: diva2:264229
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2017-12-13
Inngår i avhandling
1. Audit of Groin Hernia Repair II
Åpne denne publikasjonen i ny fane eller vindu >>Audit of Groin Hernia Repair II
2010 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Groin hernia repair is one of the most common operations performed in general  surgery, and every fourth man is expected to have a hernia operation during his lifetime. Although 8% of all repairs are performed in women, there is little published literature relating specifically to female anatomy, risk factors and techniques. There is a continuing development of new mesh materials and health care reorganization with specialized surgical clinics changing the availability of basic surgery for surgeons under training.

In 1997 a thesis was published by Anders Kald, Audit of Groin Hernia Repair, which aimed to establish an audit of hernia surgery, evaluating management, risk factors, outcome and economy. The aim of this thesis was to continue the audit of hernia surgery in Sweden, allowing evaluation of gender issues, a new mesh material, and performance of surgeons under training.

Our data showed that women have a higher incidence of emergency groin hernia repair than men, and an increased rate of femoral recurrence after an inguinal hernia repair. Time to reoperation suggests that a primary misdiagnosis is common. Detection of femoral hernias could be increased by using preperitoneal techniques, visualizing all three groin hernia locations.

Patients who received a lightweight mesh at their hernia operation had a shorter convalescence, with faster return to work and normal activity.

It might be more efficient, but not necessarily better to let a specialized hernia surgeon perform the repair. Surgical trainees had more postoperative complications, but fewer patients had chronic pain at the long-term follow-up.

Abstract [sv]

Ljumskbråcksoperationen är en av de vanligaste operationerna inom allmänkirurgi och var fjärde man förväntas bli opererad för ett bråck under sin livstid. Trots att 8% av alla operationer utförs på kvinnor, finns det sparsamt med litteratur publicerat som rör kvinnlig anatomi, riskfaktorer och operationstekniker. Det utvecklas kontinuerligt nya nätmaterial och omorganisationer inom sjukvården med specialiserade kirurgiska kliniker har förändrat tillgängligheten på allmänkirurgi för kirurger under utbildning.

1997 publicerade Anders Kald sin avhandling, Audit of Groin Hernia Repair, vilken hade som syfte att etablera en kvalitetssäkring av bråckkirurgin, med utvärdering av handläggning, riskfaktorer, resultat och ekonomi. Syftet med denna avhandling var att fortsätta kvalitetssäkra bråckkirurgin i Sverige, med utvärdering av genusfrågor, ett nytt nätmaterial och prestationen hos kirurger under utbildning.

Våra data visade att kvinnor har högre incidens av akut bråckoperation än män, och ökad frekvens av femoralbråcksrecidiv efter en inguinalbråcksoperation. Tiden till reoperation tyder på en initial feldiagnos och preperitoneala tekniker rekommenderas för att öka identifieringen av femoralbråck.

Patienter som fått ett lättviktsnät vid sin bråckoperation hade en kortare konvalesens med snabbare återgång till arbete och normala aktiviteter.

Det kan vara effektivare, men inte nödvändigtvis bättre att låta en specialiserad bråckkirurg att utföra operationen. Kirurger under utbildning hade fler postoperativa komplikationer, men färre patienter med kronisk smärta vid långtidsuppföljningen.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2010. s. 45
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1221
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-63645 (URN)978-91-7393-262-2 (ISBN)
Disputas
2010-12-15, Katastrofmedicinskt centrum, Hälsouniversitetet, Campus US, Linköpings universitet, Linköping, 09:00 (svensk)
Opponent
Veileder
Merknad

On the day of the defence date the title of article III was: "Groin hernia repair with Titanium Coated Mesh compared to Prolene Mesh: A Prospective Randomized Controlled Trial".

Tilgjengelig fra: 2010-12-29 Laget: 2010-12-29 Sist oppdatert: 2015-06-05bibliografisk kontrollert

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