liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Electronic nose for estimation of product concentration in mammalian cell cultivation
Linköpings universitet, Tekniska högskolan. Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi.ORCID-id: 0000-0001-9711-794X
2000 (engelsk)Inngår i: Bioprocess engineering (Berlin. Print), ISSN 0178-515X, E-ISSN 1432-0797, Vol. 23, nr 6, s. 637-642Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The off-gas composition from perfusion cultivation of a CHO-cell line producing recombinant human blood coagulation Factor VIII is monitored with an electronic nose. It is shown that the electronic nose in combination with an artificial neural network can be used for on-line estimation of the Factor VIII concentration in production-scale cultivations. The obtained prediction error (1s) for the Factor VIII concentration was 1.1 IU/ml. The potential of the electronic nose for estimation of viable cell count is outlined in laboratory-scale Factor VIII cultivations. The obtained prediction error (1s) for the viable cell count was 0.4 ╫ 106 cells/ml. The results show that this non-invasive method is potentially useful for on-line bioprocess monitoring.

sted, utgiver, år, opplag, sider
2000. Vol. 23, nr 6, s. 637-642
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-44219DOI: 10.1007/s004490000213Lokal ID: 76075OAI: oai:DiVA.org:liu-44219DiVA, id: diva2:265080
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2019-01-22

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Mandenius, Carl-Fredrik

Søk i DiVA

Av forfatter/redaktør
Mandenius, Carl-Fredrik
Av organisasjonen
I samme tidsskrift
Bioprocess engineering (Berlin. Print)

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 107 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf