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Accuracy and reproducibility in phase contrast imaging using SENSE
Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0001-5526-2399
Linköpings universitet, Institutionen för medicinsk teknik. Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Hälsouniversitetet.
2003 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 50, nr 5, s. 1061-1068Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The purpose of this study was to evaluate the accuracy and reproducibility of phase contrast imaging using the sensitivity encoding (SENSE) method at different reduction factors. Analytical expressions were derived that state how reproducibility is influenced for velocity and flow measurements. Computer simulations, and in vitro and in vivo studies were performed in order to validate these expressions and to assess how accuracy is affected when different reduction factors are applied. It was shown that reproducibility depends on the reduction and geometry factors. Since the geometry factor varies spatially, so does the reproducibility for phase contrast imaging. In areas with high geometry factors, the standard deviation (SD) may become so large that aliasing occurs. The accuracy of phase contrast imaging is not influenced directly when SENSE is used, but may be indirectly influenced due to high SDs of the measured phase that may subsequently cause aliasing. The current results show that it is possible to achieve accurate flow measurements even at high reduction factors. By taking the geometry factor into account, it may be possible to find areas where phase contrast imaging is accurate even at high reduction factors.

Ort, förlag, år, upplaga, sidor
2003. Vol. 50, nr 5, s. 1061-1068
Nyckelord [en]
Flow quantification, Parallel MRI, Phase contrast imaging, Reproducibility, SENSE
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-46443DOI: 10.1002/mrm.10634OAI: oai:DiVA.org:liu-46443DiVA, id: diva2:267339
Tillgänglig från: 2009-10-11 Skapad: 2009-10-11 Senast uppdaterad: 2017-12-13
Ingår i avhandling
1. Accuracy and reproducibility in phase contrast magnetic resonance imaging
Öppna denna publikation i ny flik eller fönster >>Accuracy and reproducibility in phase contrast magnetic resonance imaging
2004 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Magnetic resonance imaging (MRI) is an imaging modality which provides good conditions for studies of flow and motion in the cardiovascular system. When using the phase contrast imaging technique, it is possible to perform velocity measurements in moving tissues and in blood. The acquired velocity data can be used for subsequent calculation of different parameters used for the assessment of cardiovascular function. These parameters rely on the accuracy and reproducibility of the velocity measurements.

This thesis includes an introduction to phase contrast imaging and how displacement artifacts may hamper the accuracy of velocity measurements using phase contrast imaging. A method for correction of this artifact was developed using the knowledge of the times at which velocity and spatial encoding are carried out in the pulse sequence. The elaboration of this correction method included modifications of a 3D phase contrast pulse sequence and development of post processing algorithms involving streamline calculations. An alternative approach for correction of displacement artifacts is also presented where a pulse sequence, based on tripolar waveforms, inherently compensates for the artifact and, consequently, do not require any post processing algorithms.

The use of the sensitivity encoding (SENSE) method in MRI implies that the scanning time can be reduced dramatically. The SENSE technique can be combined with phase contrast imaging. An important question to answer is how the use of SENSE influences the accuracy and reproducibility in phase contrast imaging. In this thesis expressions are derived showing how the reproducibility of velocity and flow measurements are influenced when applying SENSE at different reduction factors.

As a consequence of the introduction of parallel imaging techniques, such as SENSE, modem MRI systems have the capability of assessing individual coil sensitivities. This information implies new alternatives in the combination of multiple phase images using phased array coils. Conventionally multiple phase images are combined using the weighted mean method, where the squared magnitude values are used as weights. In order to compare these two combination methods, theoretical and experimental studies were performed.

The results of this thesis show that corrupted velocity measurements caused by displacement artifacts can be alleviated using suggested correction methods or pulse sequences. This is of importance for subsequent flow analysis and visualization of stenotic and oblique flow. Phase contrast imaging in combination with SENSE provides opportunities to obtain large reductions in scanning times while keeping the increase of the reproducibility in the velocity and flow measurements within reasonable limits. In terms of phase reproducibility it is shown that the use of individual coil sensitivities in the combination of multiple phase images is equivalent to the conventional weighted mean method. In the accompanying magnitude images, however, signal variations due to coil sensitivities are compensated for when including estimated coil sensitivities.

Ort, förlag, år, upplaga, sidor
Linköping: Linköpings universitet, 2004. s. 73
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 899
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-29441 (URN)14787 (Lokalt ID)91-85295-41-8 (ISBN)14787 (Arkivnummer)14787 (OAI)
Disputation
2004-12-10, Wilandersalen, Universitetssjukhuset, Örebro, 10:15 (Svenska)
Opponent
Tillgänglig från: 2009-10-09 Skapad: 2009-10-09 Senast uppdaterad: 2012-12-03

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Thunberg, PerKarlsson, MattsWigström, Lars

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