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k-t2 BLAST: Exploiting spatiotemporal structure in simultaneously cardiac and respiratory time-resolved volumetric imaging
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk fysiologi. Östergötlands Läns Landsting, Hjärtcentrum, Fysiologiska kliniken. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och vård, Klinisk fysiologi. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och vård, Thoraxkirurgi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicinsk teknik, Medicinsk informatik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0002-9091-4724
2007 (Engelska)Ingår i: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 58, nr 5, s. 922-930Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Multidimensional imaging resolving both the cardiac and respiratory cycles simultaneously has the potential to describe important physiological interdependences between the heart and pulmonary processes. A fully five-dimensional acquisition with three spatial and two temporal dimensions is hampered, however, by the long acquisition time and low spatial resolution. A technique is proposed to reduce the scan time substantially by extending the k-t BLAST framework to two temporal dimensions. By sampling the k-t space sparsely in a lattice grid, the signal in the transform domain, x-f space, can be densely packed, exploiting the fact that large regions in the field of view have low temporal bandwidth. A volumetric online prospective triggering approach with full cardiac and respiratory cycle coverage was implemented. Retrospective temporal interpolation was used to refine the timing estimates for the center of k-space, which is sampled for all cardiac and respiratory time frames. This resulted in reduced reconstruction error compared with conventional k-t BLAST reconstruction. The k-t2 BLAST technique was evaluated by decimating a fully sampled five-dimensional data set, and feasibility was further demonstrated by performing sparsely sampled acquisitions. Compared to the fully sampled data, a fourfold improvement in spatial resolution was accomplished in approximately half the scan time.

Ort, förlag, år, upplaga, sidor
2007. Vol. 58, nr 5, s. 922-930
Nyckelord [en]
Cine imaging, k-t BLAST, Respiration, Volumetric MRI
Nationell ämneskategori
Teknik och teknologier Medicinsk laboratorie- och mätteknik
Identifikatorer
URN: urn:nbn:se:liu:diva-47833DOI: 10.1002/mrm.21295ISI: 000250560000009OAI: oai:DiVA.org:liu-47833DiVA, id: diva2:268729
Tillgänglig från: 2009-10-11 Skapad: 2009-10-11 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Ingår i avhandling
1. Multidimensional MRI  of Myocardial Dynamics: Acquisition, Reconstruction and Visualization
Öppna denna publikation i ny flik eller fönster >>Multidimensional MRI  of Myocardial Dynamics: Acquisition, Reconstruction and Visualization
2009 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Methods for measuring deformation and motion of the human heart in-vivo are crucial in the assessment of cardiac function. Applications ranging from basic physiological research, through early detection of disease to follow-up studies, all rely on the quality of the measurements of heart dynamics. This thesis presents new improved magnetic resonance imaging methods for acquisition, image reconstruction and visualization of cardiac motion and deformation.As the heart moves and changes shape during the acquisition, synchronization to the heart dynamics is necessary. Here, a method to resolve not only the cardiac cycle but also the respiratory cycle is presented. Combined with volumetric imaging, this produces a five-dimensional data set with two cyclic temporal dimensions. This type of data reveals unique physiological information, such as interventricular coupling in the heart in different phases of the respiratory cycle.The acquisition can also be sensitized to motion, measuring not only the magnitude of the magnetization but also a signal proportional to local velocity or displacement. This allows for quantification of the motion which is especially suitable for functional study of the cardiac deformation. In this work, an evaluation of the influence of several factors on the signal-to-noise ratio is presented for in-vivo displacement encoded imaging. Additionally, an extension of the method to acquire multiple displacement encoded slices in a single breath hold is also presented.Magnetic resonance imaging is usually associated with long scan times, and many methods exist to shorten the acquisition time while maintaining acceptable image quality. One class of such methods involves acquiring only a sparse subset of k-space. A special reconstruction is then necessary in order to obtain an artifact-free image. One family of these reconstruction techniques tailored for dynamic imaging is the k-t BLAST approach, which incorporates data-driven prior knowledge to suppress aliasing artifacts that otherwise occur with the sparse sampling. In this work, an extension of the original k-t BLAST method to two temporal dimensions is presented and applied to data acquired with full coverage of the cardio-respiratory cycles. Using this technique, termed k-t2 BLAST, simultaneous reduction of scan time and improved spatial resolution is demonstrated. Further, the loss of temporal fidelity when using the k-t BLAST approach is investigated, and an improved reconstruction is proposed for the application of cardiac function analysis.Visualization is a crucial part of the imaging chain. Scalar data, such as regular anatomical images, are straightforward to display. Myocardial strain and strain-rate, however, are tensor quantities which do not lend themselves to direct visualization. The problem of visualizing the tensor field is approached in this work by combining a local visualization that displays all degrees of freedom for a single tensor with an overview visualization using a scalar field representation of the complete tensor field. The scalar field is obtained by iterated adaptive filtering of a noise field, creating a continuous geometrical representation of the myocardial strain-rate tensor field.The results of the work presented in this thesis provide opportunities for improved imaging of myocardial function, in all areas of the imaging chain; acquisition, reconstruction and visualization.

 

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2009. s. 71
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1287
Nyckelord
MRI, Cardiac motion, myocardial dynamics, strain, tensor, deformation, DENSE, k-t BLAST
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
Identifikatorer
urn:nbn:se:liu:diva-51489 (URN)978-91-7393-494-7 (ISBN)
Disputation
2009-12-18, Conrad, Campus US, Linköpings Universitet, Linköping, 09:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2009-11-30 Skapad: 2009-11-04 Senast uppdaterad: 2020-02-19Bibliografiskt granskad
2. Multidimensional MRI of Cardiac Motion: Acquisition, Reconstruction and Visualization
Öppna denna publikation i ny flik eller fönster >>Multidimensional MRI of Cardiac Motion: Acquisition, Reconstruction and Visualization
2006 (Engelska)Licentiatavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Methods for measuring deformation and motion of the human heart in-vivo are crucial in the assessment of cardiac function. Applications ranging from basic physiological research, through early detection of disease to follow-up studies, all benefit from improved methods of measuring the dynamics of the heart. This thesis presents new methods for acquisition, reconstruction and visualization of cardiac motion and deformation, based on magnetic resonance imaging.

Local heart wall deformation can be quantified in a strain rate tensor field. This tensor field describes the local deformation excluding rigid body translation and rotation. The drawback of studying this tensor-valued quantity, as opposed to a velocity vector field, is the high dimensionality of the tensor. The problem of visualizing the tensor field is approached by combining a local visualization that displays all degrees of freedom for a single tensor with an overview visualization using a scalar field representation of the complete tensor field. The scalar field is obtained by iterated adaptive filtering of a noise field.

Several methods for synchronizing the magnetic resonance imaging acquisition to the heart beat have previously been used to resolve individual heart phases from multiple cardiac cycles. In the present work, one of these techniques is extended to resolve two temporal dimensions simultaneously, the cardiac cycle and the respiratory cycle. This is combined with volumetric imaging to produce a five-dimensional data set. Furthermore, the acquisition order is optimized in order to reduce eddy current artifacts.

The five-dimensional acquisition either requires very long scan times or can only provide low spatiotemporal resolution. A method that exploits the variation in temporal bandwidth over the imaging volume, k-t BLAST, is described and extended to two simultaneous temporal dimensions. The new method, k-t2 BLAST, allows simultaneous reduction of scan time and improvement of spatial resolution.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2006. s. 51
Serie
Linköping Studies in Science and Technology. Thesis, ISSN 0280-7971 ; 1262
Nyckelord
MRI, cardiac, motion, reconstruction
Nationell ämneskategori
Datorseende och robotik (autonoma system)
Identifikatorer
urn:nbn:se:liu:diva-7468 (URN)LIU-TEK-LIC-2006:43 (Lokalt ID)91-85523-37-2 (ISBN)LIU-TEK-LIC-2006:43 (Arkivnummer)LIU-TEK-LIC-2006:43 (OAI)
Presentation
2006-09-15, Wrannesalen, CMIV, Huvudblocket, Universitetssjukhuset, Linköping, 10:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2006-10-04 Skapad: 2006-10-04 Senast uppdaterad: 2018-01-13

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