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Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry
Lund University.
Karolinska University Hospital.
Malmö University Hospital .
Karolinska Institutet.
Vise andre og tillknytning
2009 (engelsk)Inngår i: Journal of pediatric hematology/oncology (Print), ISSN 1077-4114, E-ISSN 1536-3678, Vol. 31, nr 9, s. 696-701Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.

sted, utgiver, år, opplag, sider
2009. Vol. 31, nr 9, s. 696-701
Emneord [en]
VEGF; VEGFR-1; VEGFR-2; childhood pre-B ALL; immunohistochemistry
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-53853DOI: 10.1097/MPH.0b013e3181b258dfISI: 000269701800018OAI: oai:DiVA.org:liu-53853DiVA, id: diva2:292424
Tilgjengelig fra: 2010-02-06 Laget: 2010-02-06 Sist oppdatert: 2017-12-12

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