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Fluorescent cell-based sensing approaches for toxicity testing
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-9711-794X
2010 (engelsk)Inngår i: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 398, nr 1, s. 181-191Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Fluorimetric cell-based sensing methods have attracted increasing interest in toxicity testing of pharmaceuticals, pathogens, environmental pollutants, and other chemicals. The objective of this review is to summarise the variety of approaches reported up to now and to present recent developments in this area. The different approaches are described in relation to their underlying mechanism and, especially, to the role of the fluorophore involved. The methods discussed include the use of fluorescent or fluorogenic indicators, fluorescence-based testing for membrane integrity, approaches based on fluorescence labelling, inducible fluorescent protein expression, and analysis of cellular autofluorescence. Several of these approaches have been shown to be advantageous in comparison with non-fluorescence methods and have potential in high-throughput screening, for example in drug discovery and safety pharmacology.

sted, utgiver, år, opplag, sider
2010. Vol. 398, nr 1, s. 181-191
Emneord [en]
Fluorescence, Cytotoxicity, Alternative methods, In-vitro testing, In-vitro assays
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-58768DOI: 10.1007/s00216-010-3651-6ISI: 000280807500016PubMedID: 20354845OAI: oai:DiVA.org:liu-58768DiVA, id: diva2:345720
Tilgjengelig fra: 2010-08-26 Laget: 2010-08-26 Sist oppdatert: 2019-01-22

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