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Maternal serum concentrations of insulin-like growth factor (IGF)-I and IGF binding protein-1 before and during pregnancy in relation to maternal body weight and composition and infant birth weight
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Näringslära. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Näringslära. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0002-2273-4430
Unit of Endocrinology and Diabetology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Rolf Luft Center for Diabetes Research, Karolinska University Hospital, Stockholm, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Näringslära. Linköpings universitet, Hälsouniversitetet.
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2010 (Engelska)Ingår i: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 104, nr 6, s. 842-848Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Maternal nutritional status, e.g. body weight and composition, is associated with fetal growth. It has been suggested that the insulin-like growth factor (IGF) system may be a mediator of this relationship. In twenty-three healthy Swedish women, we studied (1) the relationships before and during pregnancy between maternal serum concentrations of IGF-I and IGF binding protein-1 (IGFBP-1) and maternal body weight and composition; (2) interactions between serum concentrations of IGF-I (before and in early pregnancy) and maternal nutritional status in relation to infant birth weight. We found that serum IGF-I during pregnancy was positively correlated with maternal body weight (r 0·47–0·56) and fat-free body weight (r 0·61–0·65), whereas serum IGFBP-1 was negatively correlated with maternal body weight (r − 0·44 to − 0·69) and body fat (r − 0·64 to − 0·76) before and during pregnancy. Women with a lower body fat content (%) before pregnancy had greater increases in serum IGFBP-1 during pregnancy than women with a higher prepregnant body fat content (%). In addition, significant fractions of the variation in corrected infant birth weight were explained by variables related to the maternal nutritional status when these were combined with serum concentrations of IGF-I in gestational week 14 (adjusted r2 0·25–0·44, P = 0·001–0·021), but not when they were combined with such concentrations before pregnancy (adjusted r2 0·11–0·12, P = 0·105–0·121). These results suggest mechanisms by which the IGF system may be a mediator between maternal nutritional status and fetal growth.

Ort, förlag, år, upplaga, sidor
Cambridge University Press , 2010. Vol. 104, nr 6, s. 842-848
Nyckelord [en]
Insulin-like growth factor-I, Insulin-like growth factor binding protein-1, Body fat, Fat-free body weight, Infant birth weight
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-60512DOI: 10.1017/S0007114510001224ISI: 000281888300009PubMedID: 20456811OAI: oai:DiVA.org:liu-60512DiVA, id: diva2:357043
Tillgänglig från: 2010-10-15 Skapad: 2010-10-15 Senast uppdaterad: 2019-06-28

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Olausson, HannaLöf, MarieForsum, ElisabetSohlström, Annica

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