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Interstitial concentration of serotonin is increased in myalgic human trapezius muscle during rest, repetitive work and mental stress - an in vivo microdialysis study
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Rehabiliteringsmedicin. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Rehabiliteringsmedicin. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Rehabiliteringsmedicin. Linköpings universitet, Hälsouniversitetet.ORCID-id: 0000-0003-2530-4126
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Yrkes- och miljömedicin. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Arbets- och miljömedicin. Linköpings universitet, Hälsouniversitetet.
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2010 (engelsk)Inngår i: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 70, nr 7, s. 478-486Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVES: The pathophysiology of trapezius myalgia is not fully elucidated. Serotonin (5-HT) is involved in modulation of nociception and hyperalgesia. Our aim was to compare the interstitial 5-HT levels of the trapezius muscle in women with chronic trapezius myalgia and in pain-free controls.

MATERIALS AND METHODS: Microdialysate of the trapezius muscle collected every 20 minutes during rest, work (100 min) and stress (20 min) was used to study the dynamics of 5-HT in women with chronic trapezius myalgia (MYA; n=18) and in pain-free controls (CON; n=30).

RESULTS: MYA had higher levels of 5-HT than CON at baseline, during repetitive work, during mental stress and during recovery. There were no significant time effects on 5-HT levels.

CONCLUSION: 5-HT has the potential of a biomarker of chronic myalgia. Elevated levels of 5-HT may be involved in maintenance of habitual chronic pain and might contribute to increased pain during exercise by facilitating the effect of released algesic substances linked to such muscle demands.

sted, utgiver, år, opplag, sider
Taylor and Francis , 2010. Vol. 70, nr 7, s. 478-486
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URN: urn:nbn:se:liu:diva-64253DOI: 10.3109/00365513.2010.511257ISI: 000283127000003OAI: oai:DiVA.org:liu-64253DiVA, id: diva2:388267
Tilgjengelig fra: 2011-01-21 Laget: 2011-01-17 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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Ghafouri, BijarLarsson, BrittSjörs, AnnaLeandersson, PerGerdle, Björn

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