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alpha-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Medicinsk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
Institute for Biochemistry, Vilnius.
2011 (Engelska)Ingår i: MOLECULAR BIOLOGY REPORTS, ISSN 0301-4851, Vol. 38, nr 5, s. 3001-3011Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Dystrobrevins (DBs) bind directly to dystrophin and are prominent components of the dystrophin-associated protein complex (DAPC) that links the cytoskeleton to the extracellular matrix. They are involved in brain development, synapse formation and plasticity, as well as water and ion homeostasis. However, the role of DB in non-muscular cells is not clear. In this study, we show that different alpha-dystrobrevin isoforms are present in promyelocytic leukemia (NB4) cells. Only the biggest alpha-dystrobrevin isoform (DB-alpha), which can be important for its function, was expressed in the membrane fraction of NB4 cells; the other alpha-DB isoforms were found in the hydrophilic cell fractions. Employing the immunoprecipitation and mass spectrometry, we identified novel alpha-DB-interacting proteins involved in cytoskeleton reorganization (actin, tropomyosin, gelsolin, tubulin) and signal transduction process (stathmin, prohibitin, RIBA) during proliferation and differentiation of NB4 cells. Our results suggest that alpha-DB isoforms play a central role in cytoskeleton reorganization via their multiple interactions with actin and actin-associating proteins and may participate in signal transduction process during NB4 cell granulocytic differentiation via directly and non directly associated proteins.

Ort, förlag, år, upplaga, sidor
Springer Science Business Media , 2011. Vol. 38, nr 5, s. 3001-3011
Nationell ämneskategori
Medicin och hälsovetenskap
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URN: urn:nbn:se:liu:diva-68340DOI: 10.1007/s11033-010-9965-9ISI: 000290102100018OAI: oai:DiVA.org:liu-68340DiVA, id: diva2:418148
Anmärkning
The original publication is available at www.springerlink.com: Veronika Borutinskaité, Karl-Eric Magnusson and R Navakauskiene, alpha-Dystrobrevin distribution and association with other proteins in human promyelocytic NB4 cells treated for granulocytic differentiation, 2011, MOLECULAR BIOLOGY REPORTS, (38), 5, 3001-3011. http://dx.doi.org/10.1007/s11033-010-9965-9 Copyright: Springer Science Business Media http://www.springerlink.com/ Tillgänglig från: 2011-05-20 Skapad: 2011-05-20 Senast uppdaterad: 2011-06-09

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Borutinskaité, VeronikaMagnusson, Karl-Eric

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