liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Towards the development of multisensor for drugs of abuse based on molecular imprinted polymers
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire, UK.
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire, UK.
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire, UK.
Institute of BioScience and Technology, Cranfield University, Silsoe, Bedfordshire, UK.
Vise andre og tillknytning
2005 (engelsk)Inngår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 542, nr 1, s. 111-117Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The synthetic receptors for cocaine, deoxyephedrine, methadone and morphine were computationally designed and produced using molecular imprinting. The structure and energy of the molecular complexes were analysed by computational techniques. The possible structures of the binding sites in the synthetic receptors have been compared with those of corresponding natural receptors. The composition of imprinted polymers was optimised to allow adequate performance under the same experimental conditions. All selected molecular imprinting polymers (MIPs) demonstrated stronger affinity in comparison with corresponding blank polymers resulting in imprinted factors (1) equal to 1.2 (cocaine), 2.5 (deoxyephedrine), 3.5 (methadone) and 3 (morphine) which suggested that the specific binding site for each molecule was successfully created. The polymers studied possessed good selectivity and affinity towards their templates and could be recommended for the integration with sensor devices. From a practical point of view, especially for multisensor requirements, the synthetic receptors based on imprinted polymers could be superior to natural receptors due to their stability, robustness and compatibility with automation processes required for sensor fabrication.

sted, utgiver, år, opplag, sider
ELSEVIER SCIENCE BV , 2005. Vol. 542, nr 1, s. 111-117
Emneord [en]
cocaine; deoxyephedrine; methadone; morphine; molecular imprinting; molecular modelling; HPLC; sensor
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-70599DOI: 10.1016/j.aca.2005.03.067ISI: 000229719200017OAI: oai:DiVA.org:liu-70599DiVA, id: diva2:440905
Tilgjengelig fra: 2011-09-14 Laget: 2011-09-14 Sist oppdatert: 2017-12-08

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Turner, Anthony P.F.

Søk i DiVA

Av forfatter/redaktør
Turner, Anthony P.F.
I samme tidsskrift
Analytica Chimica Acta

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 150 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf