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In-vivo dynamic strains of the ovine anterior mitral valve leaflet
Stanford University, USA.
Stanford University, USA.
Stanford University, USA.
Stanford University, USA.
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2011 (Engelska)Ingår i: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 44, nr 6, s. 1149-1157Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Understanding the mechanics of the mitralvalve is crucial in terms of designing and evaluating medical devices and techniques for mitralvalve repair. In the current study we characterize the in vivostrains of the anteriormitralvalveleaflet. On cardiopulmonary bypass, we sew miniature markers onto the leaflets of 57 sheep. During the cardiac cycle, the coordinates of these markers are recorded via biplane fluoroscopy. From the resulting four-dimensional data sets, we calculate areal, maximum principal, circumferential, and radial leafletstrains and display their profiles on the averaged leaflet geometry. Average peak areal strains are 13.8±6.3%, maximum principal strains are 13.0±4.7%, circumferential strains are 5.0±2.7%, and radial strains are 7.8±4.3%. Maximum principal strains are largest in the belly region, where they are aligned with the circumferential direction during diastole switching into the radial direction during systole. Circumferential strains are concentrated at the distal portion of the belly region close to the free edge of the leaflet, while radial strains are highest in the center of the leaflet, stretching from the posterior to the anterior commissure. In summary, leafletstrains display significant temporal, regional, and directional variations with largest values inside the belly region and toward the free edge. Characterizing strain distribution profiles might be of particular clinical significance when optimizing mitralvalve repair techniques in terms of forces on suture lines and on medical devices.

Ort, förlag, år, upplaga, sidor
Elsevier, 2011. Vol. 44, nr 6, s. 1149-1157
Nyckelord [en]
Mitralvalve; Strain; Kinematics; Surgical repair; Anisotropy
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-76226DOI: 10.1016/j.jbiomech.2011.01.020PubMedID: 21306716OAI: oai:DiVA.org:liu-76226DiVA, id: diva2:513046
Tillgänglig från: 2012-03-30 Skapad: 2012-03-30 Senast uppdaterad: 2017-12-07

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