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Characterization of mitral valve annular dynamics in the beating heart
Stanford University School of Engineering, USA.
Stanford University School of Engineering, USA.
Stanford University School of Engineering, USA.
Stanford University School of Engineering, USA.
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2011 (Engelska)Ingår i: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 39, nr 6, s. 1690-1702Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The objective of this study is to establish a mathematical characterization of the mitral valve annulus that allows a precise qualitative and quantitative assessment of annular dynamics in the beating heart. We define annular geometry through 16 miniature markers sewn onto the annuli of 55 sheep. Using biplane videofluoroscopy, we record marker coordinates in vivo. By approximating these 16 marker coordinates through piecewise cubic splines, we generate a smooth mathematical representation of the 55 mitral annuli. We time-align these 55 annulus representations with respect to characteristic hemodynamic time points to generate an averaged baseline annulus representation. To characterize annular physiology, we extract classical clinical metrics of annular form and function throughout the cardiac cycle. To characterize annular dynamics, we calculate displacements, strains, and curvature from the discrete mathematical representations. To illustrate potential future applications of this approach, we create rapid prototypes of the averaged mitral annulus at characteristic hemodynamic time points. In summary, this study introduces a novel mathematical model that allows us to identify temporal, regional, and inter-subject variations of clinical and mechanical metrics that characterize mitral annular form and function. Ultimately, this model can serve as a valuable tool to optimize both surgical and interventional approaches that aim at restoring mitral valve competence.

Ort, förlag, år, upplaga, sidor
New York: Springer-Verlag New York, 2011. Vol. 39, nr 6, s. 1690-1702
Nyckelord [en]
Mitral regurgitation – Mitral valve – Annulus – Dynamics – Strain – Curvature – Splines
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-76228DOI: 10.1007/s10439-011-0272-yPubMedID: 21336803OAI: oai:DiVA.org:liu-76228DiVA, id: diva2:513050
Tillgänglig från: 2012-03-30 Skapad: 2012-03-30 Senast uppdaterad: 2017-12-07Bibliografiskt granskad

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