liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Carboxylic Acids in CD-1 Mice
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Zoologi. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0001-5583-2697
2012 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, nr 3, s. e34301-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids(ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated. With all 14 odorants, the animalssignificantly discriminated concentrations as low as 0.03 ppm (parts per million) from the solvent, and with four odorantsthe best-scoring animals even detected concentrations as low as 3 ppt (parts per trillion). Analysis of odor structure-activityrelationships showed that the correlation between olfactory detection thresholds of the mice for the unbranched carboxylicacids and carbon chain length can best be described as a U-shaped function with the lowest threshold values at n-butanoicacid. A significant positive correlation between olfactory detection thresholds and carbon chain length of the carboxylicacids with their branching next to the functional carboxyl group was found. In contrast, no such correlation was found forcarboxylic acids with their branching at the distal end of the carbon chain relative to the functional carboxyl group. Finally, asignificant correlation was found between olfactory detection thresholds and the position of the branching of the carboxylicacids. Across-species comparisons suggest that mice are more sensitive for short-chained (C2 to C4) aliphatic n-carboxylicacids than other mammalian species, but not for longer-chained ones (C5 to C8). Further comparisons suggest that odorstructure-activity relationships are both substance class- and species-specific.

Ort, förlag, år, upplaga, sidor
2012. Vol. 7, nr 3, s. e34301-
Nationell ämneskategori
Naturvetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-77114DOI: 10.1371/journal.pone.0034301ISI: 000305339100146OAI: oai:DiVA.org:liu-77114DiVA, id: diva2:524956
Tillgänglig från: 2012-05-04 Skapad: 2012-05-04 Senast uppdaterad: 2017-12-07

Open Access i DiVA

fulltext(607 kB)438 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 607 kBChecksumma SHA-512
9118eb7efb3f87cf0ad7c70c927bf17782a031b353259cd2fa3b42da911b9a022e4ad355e746e39257831c2d06396ec506bbea5f612d8b8cfa7bfa97c74b9660
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltext

Personposter BETA

Laska, Matthias

Sök vidare i DiVA

Av författaren/redaktören
Laska, Matthias
Av organisationen
BiologiTekniska högskolanZoologi
I samma tidskrift
PLoS ONE
Naturvetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 438 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 338 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf